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ALKAL2 dimer [extracellular region]
Stable Identifier
R-BTA-9842604
Type
Complex
Species
Bos taurus
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
Signal Transduction (Bos taurus)
Signaling by Receptor Tyrosine Kinases (Bos taurus)
Signaling by ALK (Bos taurus)
ALK autophosphorylation (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
ALK binds ALKAL ligand (Bos taurus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK binds JAK3 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK binds PLCG1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK binds SHC1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK dimer binds IRS1 (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK phosphorylates IRS1 (Bos taurus)
Active ALK:IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:pY-IRS1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK phosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK phosphorylates PLCG1 (Bos taurus)
Active ALK:PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:p-4Y PLCG1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK phosphorylates SHC1 (Bos taurus)
Active ALK:SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:p-3Y SHC1 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK recruits PI3K (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Liganded-ALK dimer binds type I ALK-binding TKIs (Bos taurus)
ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
ligand-bound ALK dimer [plasma membrane] (Bos taurus)
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
PI3K synthesizes PIP3 downstream of ALK (Bos taurus)
Active ALK:PI3K [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
PTPN6 dephosphorylates JAK3 (Bos taurus)
Active ALK:JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
Active ALK:p-Y980 JAK3 [plasma membrane] (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
STAT3 is phosphorylated downstream of active ALK (Bos taurus)
Active ALK dimer [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
ALKAL2 dimer [extracellular region] (Bos taurus)
General
This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.
Participants
components
x 2
ALKAL2 [extracellular region]
(Bos taurus)
Participates
as an input of
ALK binds ALKAL ligand (Bos taurus)
as a component of
ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Bos taurus)
Inferred From
ALKAL2:(ALKAL1) [extracellular region]
(Homo sapiens)
ALKAL2 dimer [extracellular region]
(Homo sapiens)
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