REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides

Stable Identifier
R-HSA-9836822
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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REXO2 hydrolyzes 4-5 nucleotide RNAs to ribonucleotides
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The REXO2 dimer hydrolyzes the 4-5 nucleotide RNAs that are produced by the PNPT1 subunit of the SUPV3L1:PNPT1 complex and yields ribonucleotides (Bruni et al. 2013, Szewczyk et al. 2020, Lin et al. 2012, inferred from mouse homologs in Nicholls et al. 2019). Depletion of REXO2 causes accumulation of short (~20 nt) RNAs as well as longer noncoding RNAs transcribed from the L-strand of the mitochondrial genome (Szewczyk et al. 2020, inferred from mouse homologs in Nicholls et al. 2019).
Literature References
PubMed ID Title Journal Year
23741365 REXO2 is an oligoribonuclease active in human mitochondria

Bruni, F, Gramegna, P, Oliveira, JM, Lightowlers, RN, Chrzanowska-Lightowlers, ZM

PLoS One 2013
32365187 Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA

Szewczyk, M, Malik, D, Borowski, LS, Czarnomska, SD, Kotrys, AV, Klosowska-Kosicka, K, Nowotny, M, Szczesny, RJ

Nucleic Acids Res 2020
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Catalyst Activity

3'-5'-RNA exonuclease activity of REXO2 tetramer [mitochondrial matrix]

Physical Entity
REXO2 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
3'-5'-RNA exonuclease activity (GO:0000175)
Authored
May, B  (2023-06-05)
Reviewed
Anonymous, R  (2023-08-09)
Created
May, B  (2023-06-05)
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