Expression of SOX1 in neural plate

Stable Identifier
R-HSA-9832907
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of SOX1 in neural plate
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SOX1 is expressed at a low level in anterior and posterior neural plate, with expression in posterior neural plate slightly higher (inferred from mouse embryos). Expression then greatly increases in the posterior neural tube and anterior neural plate (inferred from mouse embryos). In embryonic stem cells, ZNF521 binds the SOX1 gene (inferred from mouse homologs) and enhances its expression (Shahbazi et al. 2016, and inferred from mouse homologs). In human embryonic stem cells, ZEB2 (SIP1) enhances expression of SOX1 and neural differentiation (Chng et al. 2010). POU3F1 also enhances expression of SOX1, though binding of POU3F1 to the SOX1 gene has not been demonstrated (inferred from mouse embryonic stem cells in Zhu et al. 2014).
Literature References
PubMed ID Title Journal Year
27052315 Conversion of Human Fibroblasts to Stably Self-Renewing Neural Stem Cells with a Single Zinc-Finger Transcription Factor

Shahbazi, E, Moradi, S, Nemati, S, Satarian, L, Basiri, M, Gourabi, H, Zare Mehrjardi, N, Günther, P, Lampert, A, Händler, K, Hatay, FF, Schmidt, D, Molcanyi, M, Hescheler, J, Schultze, JL, Saric, T, Baharvand, H

Stem Cell Reports 2016
20074535 SIP1 mediates cell-fate decisions between neuroectoderm and mesendoderm in human pluripotent stem cells

Chng, Z, Teo, A, Pedersen, RA, Vallier, L

Cell Stem Cell 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
POU3F1 [nucleoplasm] (Homo sapiens)
Regulator
ZNF521:SOX1 gene [nucleoplasm] (Homo sapiens)
Active Unit
ZNF521 [nucleoplasm]
Regulator
ZEB2 [nucleoplasm] (Homo sapiens)
Inferred From
Expression of Sox1 in neural plate (Mus musculus)
Authored
May, B  (2023-04-09)
Reviewed
Kondoh, H  (2023-07-12)
Created
May, B  (2023-04-10)
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