Reactome | Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

Stable Identifier

R-HSA-983161

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

lumenal side of endoplasmic reticulum membrane, endoplasmic reticulum lumen, endoplasmic reticulum membrane

ReviewStatus

5/5

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Dissociation of the Antigenic peptide:MHC:B2M peptide loading complex

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Upon peptide binding the class I MHC molecule releases from the peptide loading complex (PLC) and clusters at ER exit sites and is finally exported to the cell surface.
MHC I molecules bound to low-affinity peptides are not transferred to the cell surface and are instead cycled back to ER. They can proceed to the cell surface only when they become bound to high-affinity peptide (Howe et al. 2009, Garstka et al. 2007). Calreticulin binds to these low-affinity peptide bound class I molecules and mediate the retrieval from golgi apparatus to ER and for effcient presentation of a model antigen (Howe et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
2038058	Refined structure of the human histocompatibility antigen HLA-A2 at 2.6 A resolution Saper, MA, Bjorkman, PJ, Wiley, DC	J Mol Biol	1991
19851281	Calreticulin-dependent recycling in the early secretory pathway mediates optimal peptide loading of MHC class I molecules Howe, C, Garstka, M, Al-Balushi, M, Ghanem, E, Antoniou, AN, Fritzsche, S, Jankevicius, G, Kontouli, N, Schneeweiss, C, Williams, A, Elliott, T, Springer, S	EMBO J	2009
17656363	Peptide-receptive major histocompatibility complex class I molecules cycle between endoplasmic reticulum and cis-Golgi in wild-type lymphocytes Garstka, M, Borchert, B, Al-Balushi, M, Praveen, PV, Kühl, N, Majoul, I, Duden, R, Springer, S	J Biol Chem	2007
16473882	Structural definition of the H-2Kd peptide-binding motif Mitaksov, V, Fremont, DH	J Biol Chem	2006
21050182	The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding Van Hateren, A, James, E, Bailey, A, Phillips, A, Dalchau, N, Elliott, T	Tissue Antigens	2010