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Interaction of Erp57 with MHC class I HC
Stable Identifier
R-HSA-983148
Type
Reaction [binding]
Species
Homo sapiens
Compartment
lumenal side of endoplasmic reticulum membrane
,
endoplasmic reticulum lumen
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Interaction of Erp57 with MHC class I HC (Homo sapiens)
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Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.
Participants
Input
monoglucosylated MHC class I HC:Calnexin/BiP [lumenal side of endoplasmic reticulum membrane]
(Homo sapiens)
PDIA3 [endoplasmic reticulum lumen]
(Homo sapiens)
Output
MHC class I HC:Calnexin/BiP:Erp57 [lumenal side of endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as an event of
Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
Inferred From
Interaction of Erp57 with MHC class I HC (Mus musculus)
Authored
Garapati, P V (2010-10-29)
Reviewed
Elliott, T (2011-02-11)
Created
Garapati, P V (2010-10-29)
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