Reactome | TPP2 [cytosol]

TPP2 [cytosol]

Stable Identifier

R-HSA-983068

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tripeptidyl-peptidase 2, TPP2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P29144 TPP2

Gene Names

TPP2

Chain

initiator methionine:, chain:2-1249

Reference Genes

BioGPS Gene:7174 TPP2

COSMIC (genes):TPP2 TPP2

CTD Gene:7174 TPP2

dbSNP Gene:7174 TPP2

ENSEMBL:ENSG00000134900 TPP2

HGNC:12016 TPP2

KEGG:hsa:7174 TPP2

Monarch:7174 TPP2

NCBI Gene:7174 TPP2

OMIM:190470 TPP2

UCSC:P29144 TPP2

Reference Transcript

Other Identifiers

11723429_s_at

11754717_a_at

1564882_PM_at

1564882_at

1569856_3p_at

1569856_PM_at

1569856_at

1569857_PM_s_at

1569857_s_at

16776188

203374_PM_s_at

203374_s_at

203375_PM_s_at

203375_s_at

3499476

3499477

3499478

3499487

3499488

3499489

3499490

3499491

3499493

3499496

3499497

3499498

3499499

3499500

3499501

3499502

3499503

3499504

3499505

3499506

3499507

3499508

3499509

3499510

3499511

3499512

3499514

3499515

3499516

3499517

3499519

3499520

3499521

3499522

3499525

3499527

3499530

3499531

3499532

3499537

3499538

3499539

3499540

3499541

3499543

3499544

3499545

3499546

3499547

3499548

3499549

3499550

3499551

3499552

3499553

3499554

3499555

3499556

3499557

3499559

41459_at

7174

7969881

A_14_P107984

A_14_P112277

A_14_P131981

A_23_P99424

A_33_P3304754

GE58055

GO:0000209

GO:0003824

GO:0004175

GO:0004177

GO:0004252

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006508

GO:0008236

GO:0008240

GO:0016604

GO:0016787

GO:0042802

GO:0043226

GO:0080144

GO:0140096

HMNXSV003031299

HMNXSV003037035

HMNXSV003046335

Hs.1117.0.S1_3p_a_at

Hs2.382696.1.S1_3p_at

Hs2.399768.1.S1_3p_at

Hs2.399768.1.S1_3p_x_at

ILMN_1667657

ILMN_1916196

ILMN_2128358

M73047_at

PH_hs_0025236

TC13000367.hg

g4507656_3p_a_at

p4313

Participates

as a member of

IFN gamma stimulated aminopeptidases [cytosol] (Homo sapiens)

Inferred To

TPP2 [cytosol] (Bos taurus)

TPP2 [cytosol] (Canis familiaris)

TPP2 [cytosol] (Gallus gallus)

TPP2 [cytosol] (Sus scrofa)

tpp2 [cytosol] (Schizosaccharomyces pombe)

tpp2 [cytosol] (Xenopus tropicalis)

TppII [cytosol] (Drosophila melanogaster)

tpp-2 [cytosol] (Caenorhabditis elegans)

Tpp2 [cytosol] (Mus musculus)

Tpp2 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001317517.1, NP_003282.2

Guide to Pharmacology - Targets

2423

ENSEMBL

ENSP00000365233, ENST00000376065

OpenTargets

ENSG00000134900

ZINC - Substances

TPP2_HUMAN

ZINC target

P29144

PRO

P29144

GlyGen

P29144

HPA

ENSG00000134900-TPP2

Pharos - Targets

P29144

Orphanet

TPP2

ZINC - Predictions - Purchasable

TPP2_HUMAN

HMDB Protein

HMDBP14588

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P06746 POLB	2	POLB [nucleoplasm] (R-HSA-53845) PolyUb-POLB [nucleoplasm] (R-HSA-6783152)	0.781	8
UniProt:Q08426 EHHADH	2	EHHADH [peroxisomal matrix] (R-HSA-400155) EHHADH [cytosol] (R-HSA-9033147)	0.666	5
UniProt:P04798 CYP1A1	1	CYP1A1 [endoplasmic reticulum membrane] (R-HSA-52623)	0.527	2
UniProt:Q8WVK2 SNRNP27	1	SNRNP27 [nucleoplasm] (R-HSA-6806778)	0.527	2
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [secretory granule lumen] (R-HSA-6801306) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.527	2
UniProt:Q8N4J0 CARNMT1	1	CARNMT1 [cytosol] (R-HSA-8876689)	0.527	2

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