Reactome | GH2 [extracellular region]

GH2 [extracellular region]

Stable Identifier

R-HSA-982809

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Growth Hormone variant, Growth hormone 2, SOM2_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Growth hormone receptor signaling (Homo sapiens)
    - GH:GHR:JAK2 complex undergoes a conformational change (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - GHBP binds GH (Homo sapiens)
      - GHBP:GH [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Growth hormone binds the growth hormone receptor (Homo sapiens)
      - Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Growth hormone forms dimers and oligomers (Homo sapiens)
      - Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth hormone oligomer [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Growth hormone receptor binds Lyn (Homo sapiens)
      - Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - JAK2 binds STAT1/3 (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - JAK2 phosphorylates STAT1/STAT3 (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:STAT1/STAT3 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor:p(Y1007)-JAK2 dimer:p(Y701)-STAT1/p(Y705)-STAT3 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - JAK2 phosphorylation of GHR (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - JAK2 phosphorylation of IRS-1/2 (Homo sapiens)
      - Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Lyn activates ERK (Homo sapiens)
      - Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PTP1B binds the GH receptor complex (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PTP1B dephosphorylates GHR (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PTP1B dephosphorylates JAK2 (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - SOCS binding to GHR (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:CIS/SOCS1-3 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - SOCS binding to JAK2 (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SOCS [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - STAT5 association with GHR (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - STAT5 tyrosine phosphorylation (Homo sapiens)
      - Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:STAT5 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - p-STAT5A/B dissociates from the Growth Hormone receptor (Homo sapiens)
      - Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
  - Prolactin receptor signaling (Homo sapiens)
    - JAK2 phosphorylation (Homo sapiens)
      - Activated cytokine-like hormone receptors [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Homo sapiens)
        
        Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PRLR activation (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PRLR binds SCF beta-TrCP complex (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PRLR binds SHP2 (PTPN11) (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PRLR binds STAT5 (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PRLR is phosphorylated at Ser-349 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - PRLR-bound STAT5 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2:STAT5 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Prolactin receptor is internalized (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Homo sapiens)
        
        2xp-S349-PRLR:2xJAK2 [endosome lumen] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Prolactin receptor ligands bind the prolactin receptor (Homo sapiens)
      - PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - SH2B binds JAK2 (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Homo sapiens)
        
        PRLR ligands:Activated PRLR:JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - SHP2 is phosphorylated (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
        
        PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
    - Tyrosine phosphorylation of PRLR (Homo sapiens)
      - PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)
      - PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Homo sapiens)
        
        Prolactin receptor ligands [extracellular region] (Homo sapiens)
        
        Growth Hormone [extracellular region] (Homo sapiens)
        
        GH2 [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01242 GH2

Gene Names

GH2

Chain

signal peptide:1-26, chain:27-217

Reference Genes

BioGPS Gene:2689 GH2

COSMIC (genes):GH2 GH2

CTD Gene:2689 GH2

dbSNP Gene:2689 GH2

ENSEMBL:ENSG00000136487 GH2

HGNC:4262 GH2

KEGG:hsa:2689 GH2

Monarch:2689 GH2

NCBI Gene:2689 GH2

OMIM:139240 GH2

UCSC:P01242 GH2

Reference Transcript

Other Identifiers

11715337_s_at

11728434_a_at

11736579_a_at

16847676

206195_PM_x_at

206195_x_at

211151_3p_x_at

211151_x_at

211508_3p_s_at

211508_PM_s_at

211508_s_at

2689

308_f_at

309_f_at

3766455

3766466

3766468

3766469

3766470

3766471

3766472

3766473

3766474

3766475

3766477

3766478

3766479

3766482

3766484

3766487

3766496

3766513

3766514

3766517

3766520

3766526

3766528

40316_at

8017480

8180304

A_23_P207160

A_24_P216014

GE57462

GE57488

GO:0005131

GO:0005179

GO:0005576

GO:0005615

GO:0007165

GO:0008083

GO:0031667

GO:0031904

GO:0042531

GO:0045927

GO:0046427

GO:0046872

GO:0048018

GO:0048513

GO:0048856

GO:0060396

GO:0098772

HMNXSV003009803

HMNXSV003013273

HMNXSV003046399

ILMN_1659354

ILMN_1661113

ILMN_2296450

ILMN_2413473

J03756_at

PH_hs_0033166

TC17001789.hg

g12408683_3p_s_at

g12408684_3p_s_at

g12408684_3p_x_at

g12408686_3p_s_at

g12408688_3p_s_at

g12408690_3p_s_at

g12408691_3p_s_at

g12408693_3p_s_at

g12408695_3p_s_at

g12545371_3p_s_at

g12545373_3p_s_at

g12545375_3p_s_at

g12545377_3p_s_at

g12545380_3p_s_at

g13027811_3p_s_at

g13027813_3p_s_at

g13027815_3p_s_at

g13027817_3p_s_at

g13027819_3p_s_at

g13027823_3p_a_at

g13543525_3p_s_at

g2459881_3p_s_at

g2459881_3p_x_at

g9963798_3p_s_at

Participates

as a member of

Growth Hormone [extracellular region] (Homo sapiens)

Other forms of this molecule

GH2 [endosome lumen]

Inferred To

GH1 [extracellular region] (Bos taurus)

GH1 [extracellular region] (Canis familiaris)

GH1 [extracellular region] (Gallus gallus)

GH1 [extracellular region] (Mus musculus)

GH1 [extracellular region] (Rattus norvegicus)

GH1 [extracellular region] (Sus scrofa)

Homologues of GH1 [extracellular region] (Sus scrofa)

gh1 [extracellular region] (Danio rerio)

smtlb [extracellular region] (Danio rerio)

Homologues of CSH1 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_072052.1, NP_002050.1, NP_072051.1, NP_072050.1

ENSEMBL

ENST00000332800, ENSP00000333157, ENSP00000394122, ENSP00000410618, ENSP00000409294, ENST00000449787, ENST00000456543, ENST00000423893

OpenTargets

ENSG00000136487

HPA

ENSG00000136487-GH2

PRO

P01242

Pharos - Targets

P01242

GlyGen

P01242

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