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GH1 [extracellular region]
Stable Identifier
R-GGA-422070
Type
Protein [EntityWithAccessionedSequence]
Species
Gallus gallus
Compartment
extracellular region
Synonyms
P08998
Locations in the PathwayBrowser
Expand all
Immune System (Gallus gallus)
Cytokine Signaling in Immune system (Gallus gallus)
Growth hormone receptor signaling (Gallus gallus)
GH:GHR:JAK2 complex undergoes a conformational change (Gallus gallus)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
GHBP binds GH (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
GHBP:GH [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth hormone binds the growth hormone receptor (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth hormone forms dimers and oligomers (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth hormone oligomer [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
JAK2 phosphorylation (Gallus gallus)
Activated cytokine-like hormone receptors [plasma membrane] (Gallus gallus)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Gallus gallus)
Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
JAK2 phosphorylation of GHR (Gallus gallus)
Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Lyn activates ERK (Gallus gallus)
Growth Hormone:Growth Hormone Receptor-JAK2 dimer:LYN [plasma membrane] (Gallus gallus)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PTP1B binds the GH receptor complex (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PTP1B dephosphorylates GHR (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP2 [plasma membrane] (Gallus gallus)
Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
p-STAT5A/B dissociates from the Growth Hormone receptor (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Growth Hormone:Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:p-STAT5 [plasma membrane] (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Prolactin receptor signaling (Gallus gallus)
JAK2 phosphorylation (Gallus gallus)
Activated cytokine-like hormone receptors [plasma membrane] (Gallus gallus)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Activated cytokine-like hormone receptors, p-Y1007-JAK2 [plasma membrane] (Gallus gallus)
Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:Activated PRLR:p-Y1007-JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR activation (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR binds SCF beta-TrCP complex (Gallus gallus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Gallus gallus)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR is phosphorylated at Ser-349 (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Prolactin receptor is internalized (Gallus gallus)
PRLR ligands:p-S349- PRLR:JAK2 dimer [endosome lumen] (Gallus gallus)
2xp-S349-PRLR:2xJAK2 [endosome lumen] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Gallus gallus)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Prolactin receptor ligands bind the prolactin receptor (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:p-S349- PRLR:JAK2 dimer:SCF beta-TrCP complex [plasma membrane] (Gallus gallus)
PRLR ligands:p-S349-PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
SH2B binds JAK2 (Gallus gallus)
PRLR ligands:Activated PRLR:JAK2 dimer:SH2B1 beta [plasma membrane] (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
PRLR ligands:PRLR:JAK2 dimer [plasma membrane] (Gallus gallus)
Prolactin receptor ligands [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
Metabolism of proteins (Gallus gallus)
Peptide hormone metabolism (Gallus gallus)
Synthesis, secretion, and deacylation of Ghrelin (Gallus gallus)
Acyl Ghrelin and C-Ghrelin are secreted (Gallus gallus)
GH1 [extracellular region] (Gallus gallus)
External Reference Information
External Reference
UniProt:P08998
Reference Genes
BioGPS Gene:378781
ENSEMBL:ENSGALG00000000249
ENSEMBL:ENSGALG00010023602.1
ENSEMBL:ENSGALG00015027466
KEGG Gene (Gallus gallus):378781
Monarch:378781
NCBI Gene:378781
Reference Transcript
RefSeq:NM_204359.2
Other Identifiers
378781
GO:0003824
GO:0005131
GO:0005179
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005794
GO:0005802
GO:0005886
GO:0006915
GO:0008083
GO:0010628
GO:0010629
GO:0012501
GO:0016787
GO:0022414
GO:0023052
GO:0030141
GO:0031410
GO:0031667
GO:0032094
GO:0032869
GO:0035846
GO:0036211
GO:0040018
GO:0042531
GO:0043066
GO:0043226
GO:0045927
GO:0046427
GO:0046872
GO:0048018
GO:0048513
GO:0048856
GO:0050691
GO:0060396
GO:0097153
GO:0098542
GO:0098772
GO:0140096
GT_A_87_P062731
GT_A_87_P322287
Gga.1267.1.S1_a_at
Participates
as a component of
Growth Hormone:p(Y332,487,627)-Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
GHBP:GH [extracellular region] (Gallus gallus)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
Growth Hormone: Activated Growth Hormone Receptor- p(Y1007)-JAK2 dimer [plasma membrane] (Gallus gallus)
Growth Hormone: Growth Hormone Receptor-JAK2 dimer [plasma membrane] (Gallus gallus)
Placental lactogen [extracellular region] (Gallus gallus)
as an input of
Growth hormone forms dimers and oligomers (Gallus gallus)
GHBP binds GH (Gallus gallus)
Growth hormone binds the growth hormone receptor (Gallus gallus)
as a repeated unit of
Growth hormone oligomer [extracellular region] (Gallus gallus)
as a member of
Prolactin receptor ligands [extracellular region] (Gallus gallus)
This entity regulates
Negatively
Acyl Ghrelin and C-Ghrelin are secreted
(Gallus gallus)
Other forms of this molecule
CSH1 [endosome lumen]
Inferred From
CSH1 [extracellular region]
(Homo sapiens)
Growth Hormone [extracellular region]
(Homo sapiens)
GH2 [extracellular region]
(Homo sapiens)
GH1 [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_989690.1
Ensembl
ENSGALG00010023602
,
ENSGALP00010034935
,
ENSGALT00010057492
PRO
P08998
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q69283 Q69283
0.602
5
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