MITF-M dimer binds an intronic element in the PMEL gene

Stable Identifier
R-HSA-9825842
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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MITF-M dimer binds an intronic element in the PMEL gene
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The gene for PMEL (also known as SILV) is arranged in a head-to-head fashion with another MITF target gene CDK2, and the intergenic region contains E-box elements that have been shown to be bound by MITF in vitro and in vivo to promote expression of both genes (Adachi and Lieber, 2002; Du et al, 2003). MITF-M additionally binds to an E-box element present in intron 1 of the PMEL gene to stimulate gene expression as assessed by reporter assay, Northern analysis, ChIP and EMSA (Baxter and Pavan, 2003; Du et al, 2003; Strub et al, 2011; reviewed in Cheli et al, 2010).
Literature References
PubMed ID Title Journal Year
14643677 Pmel17 expression is Mitf-dependent and reveals cranial melanoblast migration during murine development

Baxter, LL, Pavan, WJ

Gene Expr Patterns 2003
21258399 Essential role of microphthalmia transcription factor for DNA replication, mitosis and genomic stability in melanoma

Strub, T, Giuliano, S, Ye, T, Bonet, C, Keime, C, Kobi, D, Le Gras, S, Cormont, M, Ballotti, R, Bertolotto, C, Davidson, I

Oncogene 2011
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
12110178 Bidirectional gene organization: a common architectural feature of the human genome

Adachi, N, Lieber, MR

Cell 2002
12819038 MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma

Du, J, Miller, AJ, Widlund, HR, Horstmann, MA, Ramaswamy, S, Fisher, DE

Am J Pathol 2003
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Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-27)
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