Reactome | p-S207 KARS displaces HINT1

p-S207 KARS displaces HINT1

Stable Identifier

R-HSA-9825788

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Binding of AP4A (P(1),P(4)-bis(5'-adenosyl) tetraphosphate(4-)) to the MITF-M repressor HINT1 displaces HINT1, liberating MITF-M to play its role in transcriptional activations (Lee et al, 2004; Carmi-Levy et al, 2008; Genovese et al, 2009; Yannay-Cohen et al, 2009; Ofir-Birin et al, 2013; reviewed in Goding and Arnheiter, 2019).

Literature References

PubMed ID	Title	Journal	Year
14975237	The function of lysyl-tRNA synthetase and Ap4A as signaling regulators of MITF activity in FcepsilonRI-activated mast cells Lee, YN, Razin, E, Nechushtan, H, Figov, N	Immunity	2004
31123060	MITF-the first 25 years Arnheiter, H, Goding, CR	Genes Dev	2019
18644867	Diadenosine tetraphosphate hydrolase is part of the transcriptional regulation network in immunologically activated mast cells Razin, E, Nechushtan, H, Kay, G, Yannay-Cohen, N, Carmi-Levy, I	Mol Cell Biol	2008
23159739	Structural switch of lysyl-tRNA synthetase between translation and transcription Nechushtan, H, Fang, P, Yang, XL, Dagan, A, Schimmel, P, Pozo, J, Razin, E, Shapiro, R, Bennett, SP, Wang, J, Ofir-Birin, Y, Guo, M, Kim, S, Song, J, Marshall, AG, Rachmin, I, Zhang, HM	Mol Cell	2013
19524539	LysRS serves as a key signaling molecule in the immune response by regulating gene expression Kemeny, DM, Yang, CM, Razin, E, Nechushtan, H, Han, JM, Kay, G, Kim, S, Yannay-Cohen, N, Carmi-Levy, I	Mol Cell	2009
22647378	The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells Sioletic, S, Sgambato, A, Cittadini, A, Rettino, A, Ghosh, P, Genovese, G, Li, H	Cell Cycle	2012