MITF-M-dependent BCL2 expression

Stable Identifier
R-HSA-9824587
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nuclear envelope, mitochondrial outer membrane
ReviewStatus
5/5
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MITF-M-dependent BCL2 expression
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MITF binds to the promoter of the BCL2 gene to upregulate its expression (McGill et al, 2002; Genovese et al, 2012). MITF-dependent regulation of the anti-apoptotic factor BCL2 contributes to the survival of the melanocyte lineage and to the progression of melanoma, as demonstrated by the loss of the melanocyte lineage in BCL2 knockout mice and in cell lines (Yamamura et al, 1996; Trisciuoglio et al, 2005; reviewed in Hou and Pavan, 2008; Cheli et al, 2010; Goding and Arnheiter, 2019; Soengas and Lowe, 2003). Overexpression of BCL2 decreases expression of the MITF target miR-211, decreases the proportion of nuclear MITF and reduces MITF occupancy on promoters of target genes such as GPR143 (also known as MLANA) and TRPM1 (De Luca et al, 2016).
Literature References
PubMed ID Title Journal Year
12086670 Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

McGill, GG, Horstmann, M, Widlund, HR, Du, J, Motyckova, G, Nishimura, EK, Lin, YL, Ramaswamy, S, Avery, W, Ding, HF, Jordan, SA, Jackson, IJ, Korsmeyer, SJ, Golub, TR, Fisher, DE

Cell 2002
8758925 Accelerated disappearance of melanocytes in bcl-2-deficient mice

Yamamura, K, Kamada, S, Ito, S, Nakagawa, K, Ichihashi, M, Tsujimoto, Y

Cancer Res 1996
19995375 Fifteen-year quest for microphthalmia-associated transcription factor target genes

Cheli, Y, Ohanna, M, Ballotti, R, Bertolotto, C

Pigment Cell Melanoma Res 2010
31123060 MITF-the first 25 years

Goding, CR, Arnheiter, H

Genes Dev 2019
15920759 Bcl-2 overexpression in melanoma cells increases tumor progression-associated properties and in vivo tumor growth

Trisciuoglio, D, Desideri, M, Ciuffreda, L, Mottolese, M, Ribatti, D, Vacca, A, Del Rosso, M, Marcocci, L, Zupi, G, Del Bufalo, D

J Cell Physiol 2005
12789290 Apoptosis and melanoma chemoresistance

Soengas, MS, Lowe, SW

Oncogene 2003
19002157 Transcriptional and signaling regulation in neural crest stem cell-derived melanocyte development: do all roads lead to Mitf?

Hou, L, Pavan, WJ

Cell Res 2008
22647378 The tumor suppressor HINT1 regulates MITF and β-catenin transcriptional activity in melanoma cells

Genovese, G, Ghosh, P, Li, H, Rettino, A, Sioletic, S, Cittadini, A, Sgambato, A

Cell Cycle 2012
26599548 miR-211 and MITF modulation by Bcl-2 protein in melanoma cells

De Luca, T, Pelosi, A, Trisciuoglio, D, D'Aguanno, S, Desideri, M, Farini, V, Di Martile, M, Bellei, B, Tupone, MG, Candiloro, A, Regazzo, G, Rizzo, MG, Del Bufalo, D

Mol Carcinog 2016
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
HDAC1:SIN3A:HINT1:MITF-M:BCL2 gene [nucleoplasm] (Homo sapiens)
Active Unit
HINT1 dimer [nucleoplasm]
HDAC1 [nucleoplasm]
SIN3A [nucleoplasm]
Positively by
Regulator
MITF-M:BCL2 gene [nucleoplasm] (Homo sapiens)
Authored
Rothfels, K  (2023-01-26)
Reviewed
Arnheiter, H  (2024-02-26)
de la Serna, IL  (2024-05-21)
Vu, HN  (2024-11-05)
Steingrímsson, E  (2024-11-05)
Created
Rothfels, K  (2023-01-20)
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