Cleaved KMT2B dimers translocate to the nucleus

Stable Identifier
R-HSA-9818578
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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Cleaved KMT2B dimers translocate to the nucleus
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The impact of TASP1-mediated cleavage on the subnuclear localization of KMT2B (also known as MLL2) has not been studied but based on protein sequence and function conservation, the effect is expected to be similar to the one observed with KMT2A (also known as MLL1 or MLL).
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Inferred From
Cleaved KMT2A dimers translocate to the nucleus (Homo sapiens)
Authored
Orlic-Milacic, M  (2023-01-06)
Reviewed
Ge, K  (2023-02-08)
Van, H  (2023-02-08)
Created
Orlic-Milacic, M  (2022-10-19)
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