Reactome | Cleaved KMT2A dimers translocate to the nucleus

Cleaved KMT2A dimers translocate to the nucleus

Stable Identifier

R-HSA-9818576

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol, nucleoplasm

ReviewStatus

5/5

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Cleaved KMT2A dimers translocate to the nucleus

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The KMT2A (also known as MLL or MLL1) dimers, produced by the cleavage of KMT2A and subsequent dimerization of two cleaved fragments, translocate to the nucleus. While cleavage and dimerization are not needed for nuclear translocation, they are required for proper subnuclear localization of KMT2A (Hsieh, Ernst et al. 2003; Hsieh, Cheng and Korsmeyer 2003).

Hsieh, Ernst et al. 2003, and Hsieh, Cheng and Korsmeyer 2003: Recombinant and endogenous human TASP1 and KMT2A proteins were used, and experiments were performed in human embryonic kidney cell line HEK293.

Literature References

PubMed ID	Title	Journal	Year
14636557	Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression Hsieh, JJ, Cheng, EH, Korsmeyer, SJ	Cell	2003
12482972	Proteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localization Hsieh, JJ, Ernst, P, Erdjument-Bromage, H, Tempst, P, Korsmeyer, SJ	Mol Cell Biol	2003