ST6GALNAC2 transfers sialic acid to Core 1 mucins

Stable Identifier
R-HSA-981814
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi lumen, Golgi membrane
Synonyms
GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ST6GALNAC2 transfers sialic acid to Core 1 mucins
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The human gene ST6GALNAC2 encodes GalNAc alpha-2,6-sialyltransferase II which mediates the transfer of sialic acid (Neu5Ac) onto the T antigen (Samyn-Petit et al. 2000).
Literature References
PubMed ID Title Journal Year
10742600 Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells

Samyn-Petit, B, Krzewinski-Recchi, MA, Steelant, WF, Delannoy, P, Harduin-Lepers, A

Biochim Biophys Acta 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

sialyltransferase activity of ST6GALNAC2 [Golgi membrane]

Physical Entity
ST6GALNAC2 [Golgi membrane] (Homo sapiens)
Activity
sialyltransferase activity (GO:0008373)
Orthologous Events
ST6GALNAC2 transfers sialic acid to Core 1 mucins (Bos taurus)
ST6GALNAC2 transfers sialic acid to Core 1 mucins (Canis familiaris)
ST6GALNAC2 transfers sialic acid to Core 1 mucins (Gallus gallus)
ST6GALNAC2 transfers sialic acid to Core 1 mucins (Mus musculus)
ST6GALNAC2 transfers sialic acid to Core 1 mucins (Rattus norvegicus)
ST6GALNAC2 transfers sialic acid to Core 1 mucins (Sus scrofa)
Cross References
RHEA
Authored
Jassal, B  (2010-10-15)
Reviewed
Ferrer, A  (2011-11-04)
D'Eustachio, P  (2025-04-08)
Created
Jassal, B  (2010-10-27)
Cite Us!