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Termination of O-glycan biosynthesis
Stable Identifier
R-HSA-977068
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
O-linked glycosylation (Homo sapiens)
O-linked glycosylation of mucins (Homo sapiens)
Termination of O-glycan biosynthesis (Homo sapiens)
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O-glycan biosynthesis can be terminated (or modified) by the addition of sialic acid residues on Core 1 and 2 glycoproteins by sialyltransferases (Varki et al. 2009).
Literature References
PubMed ID
Title
Journal
Year
20301246
Sialic Acids
Varki, A
,
Schauer, R
0
Participants
Events
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
(Homo sapiens)
ST6GALNAC2 transfers sialic acid to Core 1 mucins
(Homo sapiens)
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position
(Homo sapiens)
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen
(Homo sapiens)
Participates
as an event of
O-linked glycosylation of mucins (Homo sapiens)
Event Information
Go Biological Process
O-glycan processing (0016266)
Orthologous Events
Termination of O-glycan biosynthesis (Bos taurus)
Termination of O-glycan biosynthesis (Canis familiaris)
Termination of O-glycan biosynthesis (Danio rerio)
Termination of O-glycan biosynthesis (Drosophila melanogaster)
Termination of O-glycan biosynthesis (Gallus gallus)
Termination of O-glycan biosynthesis (Mus musculus)
Termination of O-glycan biosynthesis (Rattus norvegicus)
Termination of O-glycan biosynthesis (Sus scrofa)
Termination of O-glycan biosynthesis (Xenopus tropicalis)
Authored
Jassal, B (2010-10-15)
Reviewed
Ferrer, A (2011-11-04)
Created
Jassal, B (2010-10-15)
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