Reactome | NFE2L2 dependent SOD3 expression

NFE2L2 dependent SOD3 expression

Stable Identifier

R-HSA-9796075

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

3/5

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to chemical stress (Homo sapiens)
    - KEAP1-NFE2L2 pathway (Homo sapiens)
      - Nuclear events mediated by NFE2L2 (Homo sapiens)
        
        NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)
        
        NFE2L2 dependent SOD3 expression (Homo sapiens)

General

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SOD3 is under transcriptional control of NFE2L2 and plays role in antioxidant response in extracellular space (Singh et al, 2012, Folz et al, 1994)

Literature References

PubMed ID	Title	Journal	Year
7959763	Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene Folz, RJ, Crapo, JD	Genomics	1994
23027624	Superoxide dismutase 3 is induced by antioxidants, inhibits oxidative DNA damage and is associated with inhibition of estrogen-induced breast cancer Bhat, HK, Singh, B	Carcinogenesis	2012

Participants

Input

SOD3 gene [nucleoplasm] (Homo sapiens)

Output

SOD3 [extracellular region] (Homo sapiens)

Participates

as an event of

NFE2L2 regulating anti-oxidant/detoxification enzymes (Homo sapiens)

This event is regulated

Positively by

Regulator

NFE2L2 SOD3 gene complex [nucleoplasm] (Homo sapiens)

Active Unit

p-AcK-NFE2L2:CREBBP, EP300 [nucleoplasm]

Authored

Tiwari, K (2023-08-08)

Created

Tiwari, K (2022-08-04)

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