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Factor H displaces Bb
Stable Identifier
R-HSA-977605
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
plasma membrane
,
extracellular region
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
Factor H displaces Bb (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Factor H (CFH) greatly accelerates the displacement (decay) of Complement factor Bb from C3b.
Literature References
PubMed ID
Title
Journal
Year
1067618
Control of the amplification convertase of complement by the plasma protein beta1H
Weiler, JM
,
Fearon, DT
,
Daha, MR
,
Austen, KF
Proc Natl Acad Sci U S A
1976
Participants
Input
Cell surface:CFH, CFHR3:C3bBb [plasma membrane]
(Homo sapiens)
Output
Cell surface:FH,FHR3:C3b [plasma membrane]
(Homo sapiens)
CFB(260-764) [extracellular region]
(Homo sapiens)
Participates
as an event of
Regulation of Complement cascade (Homo sapiens)
Orthologous Events
Factor H displaces Bb in Cb:Bb complex (Gallus gallus)
Factor H displaces Bb (Bos taurus)
Factor H displaces Bb (Canis familiaris)
Factor H displaces Bb (Danio rerio)
Factor H displaces Bb (Gallus gallus)
Factor H displaces Bb (Sus scrofa)
Factor H displaces Bb (Xenopus tropicalis)
Authored
Jupe, S (2010-10-26)
Reviewed
Fraczek, LA (2012-02-13)
Bradley, DT (2012-02-13)
Created
Jupe, S (2010-10-20)
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