nsp12 acquires Fe-S cluster cofactors

Stable Identifier
R-HSA-9771686
Type
Reaction [uncertain]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
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nsp12 acquires Fe-S cluster cofactors
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The catalytic subunit nsp12 of SARS-CoV-2 RNA-dependent RNA polymerase interacts with parts of the host's iron-sulfur cluster biogenesis machinery, which facilitates Fe-S cluster transfer from the main scaffold protein, ISCU. Coordination of nsp12 with two 4Fe-4S clusters was confirmed, ligated by cysteine residues located in two sites previously identified in cryo-EM structures as zinc-binding. Functionally the clusters are required for the RNA polymerase activity of the nsp12-nsp7-nsp8 complex, in addition to presumably maintaining structure. This function can be partially restored by zinc ions (Maio et al, 2021).
Literature References
PubMed ID Title Journal Year
34083449 Fe-S cofactors in the SARS-CoV-2 RNA-dependent RNA polymerase are potential antiviral targets

Maio, N, Lafont, BAP, Sil, D, Li, Y, Bollinger, JM, Krebs, C, Pierson, TC, Linehan, WM, Rouault, TA

Science 2021
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Output
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Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
Authored
Stephan, R  (2022-04-20)
Created
Stephan, R  (2022-04-20)
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