NPAS4 stimulates NAMPT gene expression

Stable Identifier
R-HSA-9769323
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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NPAS4 stimulates NAMPT gene expression
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Based on studies in sheep (West et al. 2013) and rat (Brigidi et al. 2019) neurons, NPAS4 transcription factor, in cooperation with its heterodimerization partners ARNT, ARNT2, and ARNTL, directly stimulates transcription of the circadian rythm-controlled gene NAMPT, encoding Nicotinamide phosphoribosyltransferase.

The rhythmic production of NAD+ may function to fine-tune the daily cycles of energy storage and utilization and to coordinate these processes with the rest-activity cycle (Ramsay et al. 2009).
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Input
Output
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as an event of
This event is regulated
Positively by
Regulator
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2):NAMPT gene [nucleoplasm] (Homo sapiens)
Active Unit
(NPAS4:ARNTL,NPAS4:ARNT,NPAS4:ARNT2) [nucleoplasm]
Inferred From
NPAS4 stimulates NAMPT gene expression (Ovis aries)
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-16)
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