miR-224 represses NPAS4 mRNA translation

Stable Identifier
R-HSA-9768782
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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miR-224 represses NPAS4 mRNA translation
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miR-224 was shown to downregulate expression from the NPAS4 3'UTR reporter and to downregulate human NPAS4 at both mRNA and protein levels (Bersten et al. 2014), suggesting that it forms an endonucleolytic RISC, although the existence of a non-endonucleolytic miR-224 RISC has not been excluded. Expression of mouse Npas4 is downregulated by mouse miR-224 (Choy et al. 2017).
Literature References
PubMed ID Title Journal Year
24291638 Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

Whitelaw, ML, McCarthy, PJ, Bersten, DC, Wright, JA

Biochim Biophys Acta 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
NPAS4 mRNA:miR-224-5p RISC [cytosol] (Homo sapiens)
Active Unit
miR-224-5p RISC [cytosol]
Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-14)
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