Regulation of NPAS4 mRNA translation

Stable Identifier
R-HSA-9768778
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Regulation of NPAS4 mRNA translation
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The 3'UTR of NPAS4 mRNA is highly conserved between mouse, rat and human (>95% identity across ~700 bp of the 3'UTR sequence). Of the three putative microRNAs, miR-224, miR-203 and miR-132/212, that were predicted to target the 3'UTR of NPAS4 mRNA by multiple computational algorithms, miR-224 and miR-203 were able to significantly downregulate expression of the NPAS4 3’UTR reporter construct (Bersten et al. 2014). Downregulation of Npas4 expression by miR-224 was also shown in mouse (Choy et al. 2017). Npas4 was also reported as a target gene of miR-1 (Forget et al. 2021), miR-142 (Ji et al. 2019) and miR-744 (Choy et al. 2017). Only microRNAs that were reported to target Npas4 mRNA by at least two studies are shown in the diagram. The circulatory RNA circ_0003420 was also reported to target NPAS4 mRNA and contribute to its degradation (Xiong et al. 2021).
Literature References
PubMed ID Title Journal Year
34785784 Cell-type- and region-specific modulation of cocaine seeking by micro-RNA-1 in striatal projection neurons

Forget, B, Garcia, EM, Godino, A, Rodriguez, LD, Kappes, V, Poirier, P, Andrianarivelo, A, Marchan, ES, Allichon, MC, Marias, M, Vanhoutte, P, Girault, JA, Maldonado, R, Caboche, J

Mol Psychiatry 2021
33719821 Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4

Xiong, H, Wang, H, Yu, Q

Immunopharmacol Immunotoxicol 2021
27189618 miR-744 and miR-224 Downregulate Npas4 and Affect Lineage Differentiation Potential and Neurite Development During Neural Differentiation of Mouse Embryonic Stem Cells

Choy, FC, Klarić, TS, Koblar, SA, Lewis, MD

Mol Neurobiol 2017
24291638 Regulation of the neuronal transcription factor NPAS4 by REST and microRNAs

Bersten, DC, Wright, JA, McCarthy, PJ, Whitelaw, ML

Biochim Biophys Acta 2014
30857769 Dysregulation of miR-142 results in anxiety-like behaviors following single prolonged stress

Ji, LL, Ye, Y, Nie, PY, Peng, JB, Fu, CH, Wang, ZY, Tong, L

Behav Brain Res 2019
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Authored
Orlic-Milacic, M  (2022-04-08)
Reviewed
Lin, Y  (2022-07-29)
Created
Orlic-Milacic, M  (2022-03-14)
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