miR-9 binds CDH1 mRNA

Stable Identifier
R-HSA-9768616
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
3/5
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miR-9 binds CDH1 mRNA
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After miR-9 was computationally predicted to form a duplex with CDH1 (E-cadherin) mRNA 3'UTR (Ma et al. 2010; Liu et al. 2013; Drakaki et al. 2015; Nishioka et al. 2017), miR-9 was shown to reduce the activity of a luciferase reporter fused to the wild-type 3′ UTR of the CDH1 mRNA but not to a mutant 3′UTR carrying altered nucleotides in the miR-9 ‘seed-pairing’ recognition site.This implies that downregulation of CDH1 by miR-9 depends directly on a single cognate recognition site in the CDH1 mRNA 3′UTR (Ma et al. 2010; Liu et al. 2013; Drakaki et al. 2015). miR-9 expression and CDH1 downregulation are positively regulated by MYC and MYCN which stimulate transcription of miR-9 from the MIR9-3 gene locus (Ma et al. 2010, Liu et al. 2013, Qin et al. 2022).
Literature References
PubMed ID Title Journal Year
26206264 Functional microRNA high throughput screening reveals miR-9 as a central regulator of liver oncogenesis by affecting the PPARA-CDH1 pathway

Drakaki, A, Hatziapostolou, M, Polytarchou, C, Vorvis, C, Poultsides, GA, Souglakos, J, Georgoulias, V, Iliopoulos, D

BMC Cancer 2015
23364919 c-Myc suppressed E-cadherin through miR-9 at the post-transcriptional level

Liu, M, Zhu, H, Yang, S, Wang, Z, Bai, J, Xu, N

Cell Biol Int 2013
20173740 miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis

Ma, L, Young, J, Prabhala, H, Pan, E, Mestdagh, P, Muth, D, Teruya-Feldstein, J, Reinhardt, F, Onder, TT, Valastyan, S, Westermann, F, Speleman, F, Vandesompele, J, Weinberg, RA

Nat Cell Biol 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
MYC,MYCN:MIR9-3,MIR9-1 gene [nucleoplasm] (Homo sapiens)
Active Unit
MYC,MYCN [nucleoplasm]
Authored
Orlic-Milacic, M  (2022-03-14)
Created
Orlic-Milacic, M  (2022-03-14)
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