Dimerized phospho-IRF3, IRF7 is transported to the nucleus

Stable Identifier
R-HSA-9768142
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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Phosphorylation-induced dimerization and activation of interferon regulatory factor 3 (IRF3) or IRF7 results in the translocation of IRF3/IRF7 dimer from the cytosol into the nucleus.

SARS-CoV-2 6 (ORF6) interacts with importin KPNA2 and components of the nuclear pore complex, NUP98 and RAE1, to block nuclear translocation of transcription factors such as IRF3 (Xia H et al. 2020; Miorin L et al. 2020).

Literature References
PubMed ID Title Journal Year
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Maniatis, T, Golenbock, DT, McWhirter, SM, Latz, E, Rowe, DC, Liao, SM, Fitzgerald, KA, Faia, KL, Coyle, AJ

Nat Immunol 2003
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