Dimerized phospho-IRF3, IRF7 is transported to the nucleus

Stable Identifier
R-HSA-9768142
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol, nuclear envelope, nucleoplasm
ReviewStatus
5/5
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Dimerized phospho-IRF3, IRF7 is transported to the nucleus
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Phosphorylation-induced dimerization and activation of interferon regulatory factor 3 (IRF3) or IRF7 results in the translocation of IRF3/IRF7 dimer from the cytosol into the nucleus.

SARS-CoV-2 6 (ORF6) interacts with importin KPNA2 and components of the nuclear pore complex, NUP98 and RAE1, to block nuclear translocation of transcription factors such as IRF3 (Xia H et al. 2020; Miorin L et al. 2020).

Literature References
PubMed ID Title Journal Year
12692549 IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

Fitzgerald, KA, McWhirter, SM, Faia, KL, Rowe, DC, Latz, E, Golenbock, DT, Coyle, AJ, Liao, SM, Maniatis, T

Nat Immunol 2003
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
6:NPC [nuclear envelope] (Homo sapiens)
Active Unit
6 [cytosol]
Regulator
KPNA2:6 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Active Unit
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
Authored
Shamovsky, V  (2022-03-02)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2022-03-04)
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