6:NPC [nuclear envelope]

Stable Identifier
R-HSA-9708891
Type
Complex
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Synonyms
SARS-CoV-2 6:NPC
Locations in the PathwayBrowser
General
SARS-CoV-2 Orf6 localizes at the nuclear pore complex (NPC) and directly interacts with NUP98:RAE1 (Miorin L et al. 2020).
Literature References
PubMed ID Title Journal Year
33097660 SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling

Mena, I, Patel, RS, García-Sastre, A, Mei, M, Rosenberg, BR, Cupic, A, Makio, T, Martin-Sancho, L, Rathnasinghe, R, Sanchez-Aparicio, MT, Fontoura, BMA, Kehrer, T, Uccellini, M, Danziger, O, Chanda, SK, Schotsaert, M, White, KM, Krogan, NJ, Moreno, E, Yin, X, Miorin, L, Ren, Y, Zhang, K, Gao, S, Cohen, P, Aydillo, T, Wozniak, RW

Proc Natl Acad Sci U S A 2020
32353859 A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

Foussard, H, Beltrao, P, Koh, C, Vignuzzi, M, Peng, S, Subramanian, A, Richards, AL, Kuzuoglu-Ozturk, D, Bouhaddou, M, Melnyk, JE, Ruggero, D, Wang, HY, Venkataramanan, S, Tummino, TA, Meyer, B, O'Neal, MC, Wenzell, NA, Guo, JZ, Barrio-Hernandez, I, Huang, XP, Verba, KA, Chorba, JS, Emerman, M, Ideker, T, Lyu, J, Hernandez-Armenta, C, Fabius, JM, Obernier, K, Safari, M, Craik, CS, Dai, SA, Kim, M, Perica, T, Haas, P, Moreno, E, Zhang, Z, Cakir, M, Soucheray, M, Liu, Y, Cai, Y, Hüttenhain, R, Rosenthal, SB, Hiatt, J, Chang, JCJ, Ashworth, A, Calviello, L, Ott, M, Kortemme, T, Klippsten, S, Kaake, RM, Jang, GM, Broadhurst, DJ, Memon, D, Gordon, DE, Roth, TL, d'Enfert, C, Shi, Y, Floor, SN, Frankel, AD, Fujimori, DG, Trenker, R, Vallet, T, McGregor, MJ, Mukherjee, S, García-Sastre, A, Fletcher, SJ, Fraser, JS, Xu, J, Saltzberg, DJ, Sharp, PP, White, KM, Kirby, IT, Braberg, H, Schwartz, O, Lin, Y, Naing, ZZC, Shoichet, BK, Noack, J, Mac Kain, A, Polacco, BJ, Lou, K, Rosenberg, OS, Mathy, CJP, Bennett, MJ, Shen, W, Ganesan, SJ, Bohn, M, Savar, NS, Cavero, DA, Haas, K, Stroud, RM, Eckhardt, M, Li, Q, Young, JM, O'Meara, MJ, Miorin, L, Liboy-Lugo, J, Swaney, DL, Gross, JD, Pilla, KB, von Zastrow, M, Jacobson, M, Tutuncuoglu, B, Roesch, F, Shokat, KM, Rezelj, VV, Zhou, Y, Krogan, NJ, Roth, BL, Agard, DA, Ugur, FS, Sali, A, Malik, HS, Liu, X, Jura, N, Taunton, J, Verdin, E, Batra, J, Hubert, M, Rathore, U, Rakesh, R, Tran, QD, Shengjuler, D, Modak, M, Wankowicz, SA

Nature 2020
Participants
Participates
This entity regulates
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cite Us!