Expression of PAX2 in intermediate mesoderm

Stable Identifier
R-HSA-9761170
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Expression of PAX2 in intermediate mesoderm
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Expression of PAX2 marks the intermediate mesoderm soon after gastrulation (inferred from mouse homologs). PAX2 is required for differentiation of intermediate mesoderm and mice lacking Pax2 fail to develop kidneys, ureters, and genital tracts (Torres et al. 1995). In intermediate mesoderm, PAX2 expression is activated by OSR1, LHX1, BMP4, and retinoic acid (inferred from mouse homologs). LHX1 does not affect expression of PAX2 at late development of the kidney (inferred from mouse homologs).
In induced human pluripotent stem cells in vitro, PAX2 expression is activated by FGF2 and retinoic acid (Lam et al. 2014).
Literature References
PubMed ID Title Journal Year
24357672 Rapid and efficient differentiation of human pluripotent stem cells into intermediate mesoderm that forms tubules expressing kidney proximal tubular markers

Lam, AQ, Freedman, BS, Morizane, R, Lerou, PH, Valerius, MT, Bonventre, JV

J Am Soc Nephrol 2014
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
FGF2(143-288) [extracellular region] (Homo sapiens)
Regulator
LHX1 [nucleoplasm] (Homo sapiens)
Regulator
OSR1 [nucleoplasm] (Homo sapiens)
Regulator
BMP4 dimer [extracellular region] (Homo sapiens)
Regulator
atRA [extracellular region]
Inferred From
Expression of Pax2 in intermediate mesoderm (Mus musculus)
Authored
May, B  (2022-01-10)
Reviewed
Tam, PPL  (2023-05-03)
Created
May, B  (2022-01-11)
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