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UBE3C [cytosol]
Stable Identifier
R-HSA-976012
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ubiquitin-protein ligase E3C, UBE3C_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
UBE3C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15386 UBE3C
Gene Names
UBE3C, KIAA0010, KIAA10
Chain
chain:1-1083
Reference Genes
BioGPS Gene:9690 UBE3C
COSMIC (genes):UBE3C UBE3C
CTD Gene:9690 UBE3C
dbSNP Gene:9690 UBE3C
ENSEMBL:ENSG00000009335 UBE3C
HGNC:16803 UBE3C
KEGG:hsa:9690 UBE3C
Monarch:9690 UBE3C
NCBI Gene:9690 UBE3C
OMIM:614454 UBE3C
UCSC:Q15386 UBE3C
Reference Transcript
RefSeq:NM_014671.2 UBE3C
Other Identifiers
11722029_a_at
11722030_a_at
11746615_a_at
11750891_a_at
1554793_PM_at
1554793_at
1554794_PM_a_at
1554794_a_at
1555405_PM_at
1555405_at
17054040
201817_PM_at
201817_at
243519_PM_at
243519_at
3033925
3033926
3033927
3033928
3033929
3033934
3033935
3033936
3033937
3033938
3033939
3033940
3033941
3033942
3033943
3033944
3033945
3033948
3033955
3033957
3033958
3033961
3033962
3033963
3033964
3033965
3033968
3033969
3033970
3033971
3033972
3033973
3033974
3033975
3033977
3033978
3033979
3033985
3033986
3033991
3033993
3033995
3034008
3034009
3034010
3034011
3034012
3034022
32044_at
3809800
7893281
8137596
9690
A_14_P126501
A_23_P59481
A_24_P212443
A_24_P265135
D13635_at
GE57066
GO:0000209
GO:0000502
GO:0003824
GO:0004842
GO:0005515
GO:0006511
GO:0016567
GO:0016740
GO:0035519
GO:0061630
GO:0070936
GO:0140096
HMNXSV003021933
Hs.290835.0.A1_3p_at
Hs2.155287.2.S1_3p_at
Hs2.155287.3.S1_3p_at
ILMN_1704342
PH_hs_0009355
TC07001054.hg
g7661855_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Dmel\CG3356 [cytosol]
(Drosophila melanogaster)
UBE3C [cytosol]
(Bos taurus)
UBE3C [cytosol]
(Canis familiaris)
UBE3C [cytosol]
(Gallus gallus)
UBE3C [cytosol]
(Plasmodium falciparum)
UBE3C [cytosol]
(Schizosaccharomyces pombe)
UBE3C [cytosol]
(Sus scrofa)
Ube3c [cytosol]
(Mus musculus)
Ube3c [cytosol]
(Rattus norvegicus)
ube3a [cytosol]
(Xenopus tropicalis)
etc-1 [cytosol]
(Caenorhabditis elegans)
HUL5 [cytosol]
(Saccharomyces cerevisiae)
Cross References
RefSeq
NP_055486.2
ENSEMBL
ENST00000348165
,
ENSP00000373755
,
ENSP00000309198
,
ENST00000389103
OpenTargets
ENSG00000009335
HPA
ENSG00000009335-UBE3C
PRO
Q15386
Pharos - Targets
Q15386
GlyGen
Q15386
HMDB Protein
HMDBP09330
PDB
6K2C
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.527
4
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