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PJA1 [cytosol]
Stable Identifier
R-HSA-975989
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase Praja-1, PJA1_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PJA1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8NG27 PJA1
Gene Names
PJA1, RNF70
Chain
chain:1-643
Reference Genes
BioGPS Gene:64219 PJA1
COSMIC (genes):PJA1 PJA1
CTD Gene:64219 PJA1
dbSNP Gene:64219 PJA1
ENSEMBL:ENSG00000181191 PJA1
ENSEMBL_homo_sapiens_GENE:ENSG00000181191.12 PJA1
HGNC:16648 PJA1
Monarch:64219 PJA1
NCBI Gene:64219 PJA1
OMIM:300420 PJA1
UCSC:Q8NG27 PJA1
Reference Transcript
RefSeq:XM_005262292.1 PJA1
RefSeq:NM_022368.4 PJA1
RefSeq:XM_011531011.2 PJA1
RefSeq:NM_145119.3 PJA1
RefSeq:NM_001032396.2 PJA1
Other Identifiers
11724715_a_at
11745104_a_at
11747238_a_at
11759869_x_at
17111769
218667_PM_at
218667_at
4011465
4011466
4011467
4011468
4011469
4011470
4011471
4011472
4011473
4011474
4011475
4011477
49434_at
64219
8173340
A_23_P11244
A_33_P3217347
GE82683
GO:0003824
GO:0005515
GO:0005737
GO:0016740
GO:0030163
GO:0046872
GO:0061630
GO:0140096
HMNXSV003046392
ILMN_1667261
ILMN_1734810
ILMN_2373566
PH_hs_0001820
TC0X001106.hg
g11641292_3p_at
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Pja1 [cytosol]
(Mus musculus)
Pja1 [cytosol]
(Rattus norvegicus)
PJA1 [cytosol]
(Bos taurus)
PJA1 [cytosol]
(Dictyostelium discoideum)
PJA1 [cytosol]
(Gallus gallus)
PJA1 [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_011529313.1
,
NP_071763.2
,
NP_660095.1
,
XP_005262349.1
,
NP_001027568.1
OpenTargets
ENSG00000181191
HPA
ENSG00000181191-PJA1
GeneCards
Q8NG27
Ensembl
ENSG00000181191
,
ENSP00000363699
,
ENSP00000363711
,
ENSP00000363712
,
ENST00000361478
,
ENST00000374583
,
ENSP00000355014
,
ENST00000374571
,
ENST00000374584
PRO
Q8NG27
Pharos - Targets
Q8NG27
PDB
2L0B
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.74
7
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