Addition of GlcNAc to position 5 by MGAT5

Stable Identifier
R-HSA-975916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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N-acetylglucosaminyltransferase (GnT)-V catalyzes the addition of GlcNAc beta 1,4 on the GlcNAc beta1,2 Man,alpha1,6 arm of complex type N-Glycans (Park C et al, 1999; Granowski M et al, 2000; Wang L et al, 2007). The activity of MGAT5 competes with MGAT3 (Pinho SS et al, 2009) and is associated with gastric cancer (Tian H et al, 2008) and multiple sclerosis (Brynedal B et al, 2010).

Literature References
PubMed ID Title Journal Year
19403558 The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

Pinho, SS, Reis, CA, Paredes, J, Magalhães, AM, Ferreira, AC, Figueiredo, J, Xiaogang, W, Carneiro, F, Gärtner, F, Seruca, R

Hum Mol Genet 2009
18931531 The implication of N-acetylglucosaminyltransferase V expression in gastric cancer

Tian, H, Miyoshi, E, Kawaguchi, N, Shaker, M, Ito, Y, Taniguchi, N, Tsujimoto, M, Matsuura, N

Pathobiology 2008
10700233 Suppression of tumor growth and metastasis in Mgat5-deficient mice

Granovsky, M, Fata, J, Pawling, J, Muller, WJ, Khokha, R, Dennis, JW

Nat Med 2000
20117844 MGAT5 alters the severity of multiple sclerosis

Brynedal, B, Wojcik, J, Esposito, F, Debailleul, V, Yaouanq, J, Martinelli-Boneschi, F, Edan, G, Comi, G, Hillert, J, Abderrahim, H

J Neuroimmunol 2010
16924681 Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721

Wang, L, Liang, Y, Li, Z, Cai, X, Zhang, W, Wu, G, Jin, J, Fang, Z, Yang, Y, Zha, X

J Cell Biochem 2007
10395745 Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B

Park, C, Jin, UH, Lee, YC, Cho, TJ, Kim, CH

Arch Biochem Biophys 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity of MGAT5 [Golgi membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created