Addition of GlcNAc to position 5 by MGAT5

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
N-acetylglucosaminyltransferase (GnT)-V catalyzes the addition of GlcNAc beta 1,4 on the GlcNAc beta1,2 Man,alpha1,6 arm of complex type N-Glycans (Park C et al, 1999; Granowski M et al, 2000; Wang L et al, 2007). The activity of MGAT5 competes with MGAT3 (Pinho SS et al, 2009) and is associated with gastric cancer (Tian H et al, 2008) and multiple sclerosis (Brynedal B et al, 2010).
Literature References
PubMed ID Title Journal Year
18931531 The implication of N-acetylglucosaminyltransferase V expression in gastric cancer

Tsujimoto, M, Miyoshi, E, Matsuura, N, Taniguchi, N, Ito, Y, Shaker, M, Kawaguchi, N, Tian, H

Pathobiology 2008
19403558 The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin

Magalhães, AM, Figueiredo, J, Carneiro, F, Xiaogang, W, Ferreira, AC, Gärtner, F, Reis, CA, Seruca, R, Paredes, J, Pinho, SS

Hum Mol Genet 2009
10700233 Suppression of tumor growth and metastasis in Mgat5-deficient mice

Muller, WJ, Khokha, R, Granovsky, M, Dennis, JW, Pawling, J, Fata, J

Nat Med 2000
20117844 MGAT5 alters the severity of multiple sclerosis

Martinelli-Boneschi, F, Brynedal, B, Edan, G, Comi, G, Wojcik, J, Hillert, J, Yaouanq, J, Debailleul, V, Esposito, F, Abderrahim, H

J Neuroimmunol 2010
16924681 Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721

Zha, X, Wu, G, Cai, X, Liang, Y, Zhang, W, Jin, J, Yang, Y, Li, Z, Wang, L, Fang, Z

J Cell Biochem 2007
10395745 Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B

Kim, CH, Lee, YC, Cho, TJ, Park, C, Jin, UH

Arch Biochem Biophys 1999
Catalyst Activity

alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity of MGAT5 [Golgi membrane]

Orthologous Events
Cite Us!