Reactome | N-Glycan antennae elongation

N-Glycan antennae elongation

Stable Identifier

R-HSA-975577

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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N-glycans are further modified after the commitment to Complex or Hybrid N-glycans. The exact structure of the network of metabolic reactions involved is complex and not yet validated experimentally. Here we will show a generic reaction for each of the genes known to be involved in N-Glycosylation.
For a better annotation of the reactions and genes involved in the synthesis of Complex and Hybrid N-glycans we recommend the GlycoGene Database (Ito H. et al, 2010) (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotations of genes, and the Consortium for Functional Genomics (http://riodb.ibase.aist.go.jp/rcmg/ggdb/textsearch.jsp) for annotation of Glycan structures and reactions. Moreover, a computationally inferred prediction for the structure of this network is available through the software GlycoVis (Hossler P. et. al. 2006).

Literature References

PubMed ID	Title	Journal	Year
16807922	GlycoVis: visualizing glycan distribution in the protein N-glycosylation pathway in mammalian cells Hu, WS, Lee, MM, Hossler, P, Goh, LT	Biotechnol Bioeng	2006
20816477	In vitro and in vivo enzymatic syntheses and mass spectrometric database for N-glycans and o-glycans Ito, H, Narimatsu, H, Sato, T, Kameyama, A, Chiba, Y	Methods Enzymol	2010