Reactome | Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV

Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV

Stable Identifier

R-HSA-975903

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        N-Glycan antennae elongation (Homo sapiens)
        
        Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV (Homo sapiens)

General

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Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV

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N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addition of GlcNAc beta,1,4 on the GlcNAc beta1,2 Man,alpha1,3 arm of both complex and hybrid N-glycans (Oguri S et al, 2006). Two human GnT-IV isozymes have been characterized (MGAT4A, MGAT4B) , plus a putative MGAT4C on chromosome 2 (Furukawa T et al, 1999). Aberrant expression of MGAT4A or MGAT4B is associated with pancreatic cancer (Ide Y et al, 2006; Kudo T et al , 2007)

Literature References

PubMed ID	Title	Journal	Year
10570912	Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene Furukawa, T, Youssef, EM, Yatsuoka, T, Yokoyama, T, Makino, N, Inoue, H, Fukushige, S, Hoshi, M, Hayashi, Y, Sunamura, M, Horii, A	J Hum Genet	1999
17488527	N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma Kudo, T, Nakagawa, H, Takahashi, M, Hamaguchi, J, Kamiyama, N, Yokoo, H, Nakanishi, K, Nakagawa, T, Kamiyama, T, Deguchi, K, Nishimura, S, Todo, S	Mol Cancer	2007
16434023	Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer Ide, Y, Miyoshi, E, Nakagawa, T, Gu, J, Tanemura, M, Nishida, T, Ito, T, Yamamoto, H, Kozutsumi, Y, Taniguchi, N	Biochem Biophys Res Commun	2006
17006639	Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes Oguri, S, Yoshida, A, Minowa, MT, Takeuchi, M	Glycoconj J	2006