Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV

Stable Identifier
R-HSA-975903
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addition of GlcNAc beta,1,4 on the GlcNAc beta1,2 Man,alpha1,3 arm of both complex and hybrid N-glycans (Oguri S et al, 2006). Two human GnT-IV isozymes have been characterized (MGAT4A, MGAT4B) , plus a putative MGAT4C on chromosome 2 (Furukawa T et al, 1999). Aberrant expression of MGAT4A or MGAT4B is associated with pancreatic cancer (Ide Y et al, 2006; Kudo T et al , 2007)

Literature References
PubMed ID Title Journal Year
17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma

Kudo, T, Nakagawa, H, Takahashi, M, Hamaguchi, J, Kamiyama, N, Yokoo, H, Nakanishi, K, Nakagawa, T, Kamiyama, T, Deguchi, K, Nishimura, S, Todo, S

Mol Cancer 2007
10570912 Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene

Furukawa, T, Youssef, EM, Yatsuoka, T, Yokoyama, T, Makino, N, Inoue, H, Fukushige, S, Hoshi, M, Hayashi, Y, Sunamura, M, Horii, A

J Hum Genet 1999
16434023 Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer

Ide, Y, Miyoshi, E, Nakagawa, T, Gu, J, Tanemura, M, Nishida, T, Ito, T, Yamamoto, H, Kozutsumi, Y, Taniguchi, N

Biochem Biophys Res Commun 2006
17006639 Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes

Oguri, S, Yoshida, A, Minowa, MT, Takeuchi, M

Glycoconj J 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity of MGAT4s [Golgi membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created