Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV

Stable Identifier
Reaction [transition]
Homo sapiens
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N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addition of GlcNAc beta,1,4 on the GlcNAc beta1,2 Man,alpha1,3 arm of both complex and hybrid N-glycans (Oguri S et al, 2006). Two human GnT-IV isozymes have been characterized (MGAT4A, MGAT4B) , plus a putative MGAT4C on chromosome 2 (Furukawa T et al, 1999). Aberrant expression of MGAT4A or MGAT4B is associated with pancreatic cancer (Ide Y et al, 2006; Kudo T et al , 2007)
Literature References
PubMed ID Title Journal Year
10570912 Cloning and characterization of the human UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homologue (hGnT-IV-H) gene

Hayashi, Y, Hoshi, M, Fukushige, S, Horii, A, Yokoyama, T, Inoue, H, Yatsuoka, T, Makino, N, Furukawa, T, Sunamura, M, Youssef, EM

J Hum Genet 1999
17488527 N-glycan alterations are associated with drug resistance in human hepatocellular carcinoma

Deguchi, K, Nakagawa, T, Nakagawa, H, Kudo, T, Hamaguchi, J, Nishimura, S, Nakanishi, K, Kamiyama, N, Yokoo, H, Takahashi, M, Todo, S, Kamiyama, T

Mol Cancer 2007
16434023 Aberrant expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer

Nakagawa, T, Tanemura, M, Kozutsumi, Y, Miyoshi, E, Gu, J, Nishida, T, Yamamoto, H, Taniguchi, N, Ide, Y, Ito, T

Biochem Biophys Res Commun 2006
17006639 Kinetic properties and substrate specificities of two recombinant human N-acetylglucosaminyltransferase-IV isozymes

Oguri, S, Minowa, MT, Takeuchi, M, Yoshida, A

Glycoconj J 2006
Catalyst Activity

alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity of MGAT4s [Golgi membrane]

Orthologous Events
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