Acetylsalicylic acid dissolves

Stable Identifier
R-HSA-9757434
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Acetylsalicylic acid dissolves
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Aspirin (acetylsalicylic acid) is classified as "highly soluble", meaning that the highest therapeutically used single dose (1000 mg) dissolves in 250 ml of water to its ionized form acetylsalicylate (ASA-). ASA- in solution has an increased rate of uptake versus aspirin in tablet form and poses fewer risks to the stomach (Leonards, 1963; Dressman et al, 2012).
Literature References
PubMed ID Title Journal Year
22674043 Biowaiver monograph for immediate-release solid oral dosage forms: acetylsalicylic acid

Dressman, JB, Nair, A, Abrahamsson, B, Barends, DM, Groot, DW, Kopp, S, Langguth, P, Polli, JE, Shah, VP, Zimmer, M

J Pharm Sci 2012
13929721 The influence of solubility on the rate of gastrointestinal absorption of aspirin

LEONARDS, JR

Clin Pharmacol Ther 1963
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Authored
Stephan, R  (2021-08-03)
Reviewed
Huddart, R  (2021-10-13)
Created
Shamovsky, V  (2021-11-01)
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