Reactome | MCM3 binds MCM5

MCM3 binds MCM5

Stable Identifier

R-HSA-9757256

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

MCM3 can form a complex with MCM5 in the absence of other MCM complex subunits. This complex does not possess a DNA helicase activity (Sato et al. 2000). The complex of MCM3 and MCM5 was reported to play a role in transcriptional regulation in addition to its involvement in DNA replication (DaFonseca and Zhang 2001).

Literature References

PubMed ID	Title	Journal	Year
10884341	Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex. Ishimi, Y, Gotow, T, Komamura-Kohno, Y, You, Z, Sato, M, Nojima, H, Uchiyama, Y, Yabuta, N	J Mol Biol	2000
11248027	Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma Zhang, JJ, DaFonseca, CJ, Shu, F	Proc Natl Acad Sci U S A	2001