Reactome | MCM3 binds MCM5

MCM3 binds MCM5

Stable Identifier

R-HSA-9757256

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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MCM3 can form a complex with MCM5 in the absence of other MCM complex subunits. This complex does not possess a DNA helicase activity (Sato et al. 2000). The complex of MCM3 and MCM5 was reported to play a role in transcriptional regulation in addition to its involvement in DNA replication (DaFonseca and Zhang 2001).

Literature References

PubMed ID	Title	Journal	Year
10884341	Electron microscopic observation and single-stranded DNA binding activity of the Mcm4,6,7 complex. Sato, M, Gotow, T, You, Z, Komamura-Kohno, Y, Uchiyama, Y, Yabuta, N, Nojima, H, Ishimi, Y	J Mol Biol	2000
11248027	Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma DaFonseca, CJ, Shu, F, Zhang, JJ	Proc Natl Acad Sci U S A	2001