N binds to heme

Stable Identifier
R-HSA-9756470
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
N binds to heme
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SARS-CoV-2 nucleocapsid (N) protein can bind to heme, as identified through shotgun proteomics. We placed the interaction in the cytosol as the most likely compartment because of N abundance. However, possible N protein binding to heme in the nucleus might have an important implication in viral and cellular transcriptional regulation since heme regulates multiple transcription factors in the nucleus, modulating the expression of various genes (Lechuga et al, 2021).
Literature References
PubMed ID Title Journal Year
34445741 SARS-CoV-2 Proteins Bind to Hemoglobin and Its Metabolites

Napoleão-Pêgo, P, Lechuga, GC, Souza-Silva, F, Fintelman-Rodrigues, N, Dias, SSG, Trugilho, MRO, Sacramento, CQ, Pereira, MCS, Souza, TML, De-Simone, SG, Carels, N, Valente, RH, Temerozo, JR, Provance, DW, Alves, CR

Int J Mol Sci 2021
Participants
Input
Output
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Shamovsky, V  (2021-10-27)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2021-10-14)
Cite Us!