Severe acute respiratory syndrome coronavirus type 2 (SARS‑CoV‑2) encodes several proteins that modulate host intracellular signaling and regulatory pathways. Among them are membrane M, nucleocapsid N and 3a proteins that directly bind to host targets associated with SARS‑CoV‑2 infection and cytokine production. This Reactome module describes several such binding events and their consequences. First, SARS‑CoV‑2 M binds to 3‑phosphoinositide‑dependent protein kinase 1 (PDPK1) to inhibit PKB/Akt activation (Ren Y et al. 2021). Second, SARS‑CoV‑1 N binds to the host 14-3-3 protein, which regulates nucleocytoplasmic shuttling and other functions of N (Tugaeva KV et al. 2021). Third, binding of viral 3a to the regulator and scaffolding protein caveolin‑1 (CAV1) may regulate virus uptake as well as the trafficking of viral structural proteins (inferred from the orthologous protein in SARS-CoV-1).
Tugaeva, KV, Ker, DS, Bayfield, OW, Smith, JLR, Antson, AA, Sysoev, AA, Klychnikov, OI, Sluchanko, NN, Hawkins, DEDP
Wu, D, Shu, T, Wang, A, Qiu, Y, Huang, M, Zhou, X, Jin, L, Fang, Y, Ren, Y, Zhou, W, Min, J, Wang, C
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