Reactome | RDH11 reduces RBP2:atRAL to RBP2:atROL

RDH11 reduces RBP2:atRAL to RBP2:atROL

Stable Identifier

R-HSA-975629

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

ReviewStatus

5/5

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Although the enzyme catalysing retinal reduction in human enterocytes is not identified, the best candidate is retinol dehydrogenase 11 (RDH11, RalR1). It is expressed in the intestine, has a basic pH optimum, and localises to the ER membrane where LRAT catalyses the next step in the pathway. However, RDH11 catalyses retinal reduction to retinol in vitro and uses NADPH as cofactor (Fierce et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
18295589	In vitro and in vivo characterization of retinoid synthesis from beta-carotene Piantedosi, R, Wyss, A, de Morais Vieira, M, Fierce, Y, Paik, J, Blaner, WS	Arch Biochem Biophys	2008