RDH11 reduces RBP2:atRAL to RBP2:atROL

Stable Identifier
R-HSA-975629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Although the enzyme catalysing retinal reduction in human enterocytes is not identified, the best candidate is retinol dehydrogenase 11 (RDH11, RalR1). It is expressed in the intestine, has a basic pH optimum, and localises to the ER membrane where LRAT catalyses the next step in the pathway. However, RDH11 catalyses retinal reduction to retinol in vitro and uses NADPH as cofactor (Fierce et al. 2008).

Literature References
PubMed ID Title Journal Year
18295589 In vitro and in vivo characterization of retinoid synthesis from beta-carotene

Fierce, Y, de Morais Vieira, M, Piantedosi, R, Wyss, A, Blaner, WS, Paik, J

Arch Biochem Biophys 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor of RDH11 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
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