GABA receptor activation

Stable Identifier
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that act via the inhibitory action of their Galpha/Go subunits on adenylate cyclase to attenuate the actions of PKA. In addition, their Gbeta/gamma subunits interact directly with N and P/Q Ca2+ channels to decrease the release of Ca2+. GABA B receptors also interact with Kir3 K+ channels and increase the influx of K+, leading to cell membrane hyperpolarization and inhibition of channels such as NMDA receptors (A Pinard et al Adv Pharmacol, 58, 2010, 231-55).

Literature References
PubMed ID Title Journal Year
20655481 GABAB receptor coupling to G-proteins and ion channels

Slesinger, PA, Padgett, CL

Adv Pharmacol 2010
17364682 GABAA receptors: properties and trafficking

Michels, G, Moss, SJ

Crit Rev Biochem Mol Biol 2007
15269338 Molecular structure and physiological functions of GABA(B) receptors

Bettler, B, Kaupmann, K, Gassmann, M, Mosbacher, J

Physiol Rev 2004
11283747 Constructing inhibitory synapses

Smart, TG, Moss, SJ

Nat Rev Neurosci 2001
20655485 GABAB receptors: physiological functions and mechanisms of diversity

Bettler, B, Pinard, A, Seddik, R

Adv Pharmacol 2010
Event Information
Orthologous Events
Cite Us!