Reactome | GABA receptor activation

GABA receptor activation

Stable Identifier

R-HSA-977443

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

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Gamma aminobutyric acid (GABA) receptors are the major inhibitory receptors in human synapses. They are of two types. GABA A receptors are fast-acting ligand gated chloride ion channels that mediate membrane depolarization and thus inhibit neurotransmitter release (G Michels et al Crit Rev Biochem Mol Biol 42, 2007, 3-14). GABA B receptors are slow acting metabotropic Gprotein coupled receptors that act via the inhibitory action of their Galpha/Go subunits on adenylate cyclase to attenuate the actions of PKA. In addition, their Gbeta/gamma subunits interact directly with N and P/Q Ca2+ channels to decrease the release of Ca2+. GABA B receptors also interact with Kir3 K+ channels and increase the influx of K+, leading to cell membrane hyperpolarization and inhibition of channels such as NMDA receptors (A Pinard et al Adv Pharmacol, 58, 2010, 231-55).

Literature References

PubMed ID	Title	Journal	Year
20655481	GABAB receptor coupling to G-proteins and ion channels Slesinger, PA, Padgett, CL	Adv Pharmacol	2010
17364682	GABAA receptors: properties and trafficking Michels, G, Moss, SJ	Crit Rev Biochem Mol Biol	2007
15269338	Molecular structure and physiological functions of GABA(B) receptors Bettler, B, Kaupmann, K, Gassmann, M, Mosbacher, J	Physiol Rev	2004
11283747	Constructing inhibitory synapses Smart, TG, Moss, SJ	Nat Rev Neurosci	2001
20655485	GABAB receptors: physiological functions and mechanisms of diversity Bettler, B, Pinard, A, Seddik, R	Adv Pharmacol	2010