First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9

Stable Identifier
R-HSA-975180
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus, Human immunodeficiency virus 1, Human SARS coronavirus
Compartment
endosome membrane, cytosol
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First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
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First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.

Literature References
PubMed ID Title Journal Year
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Li, S, Strelow, A, Fontana, EJ, Wesche, H

Proc Natl Acad Sci U S A 2002
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU

J Biol Chem 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
Physical Entity
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]
Activity
protein serine/threonine kinase activity (0004674)
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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