First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9

Stable Identifier
R-HSA-975180
Type
Reaction
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
endosome membrane, cytosol
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First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9
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First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.

Literature References
PubMed ID Title Journal Year
14625308 Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling

Wesche, H, Li, S, Martin, MU, Knop, J, Neumann, D, Cao, P, Mackensen, AC, Kollewe, C

J Biol Chem 2004
11960013 IRAK-4: a novel member of the IRAK family with the properties of an

Wesche, H, Li, S, Fontana, EJ, Strelow, A

Proc Natl Acad Sci U S A 2002
Participants
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Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane]

Physical Entity
IRAK1:p-S,2T-IRAK4 :oligo-MyD88:activated TLR 7/8 or 9 [endosome membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
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