Reactome | First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9

First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9

Stable Identifier

R-HSA-975180

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endosome membrane, cytosol

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First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9

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First, IRAK1 is phosphorylated at Thr209 by IRAK4. This results in a conformational change of the kinase domain, permitting further phosphorylations to take place. Substitution of Thr209 by alanine results in a kinase-inactive IRAK1.

Literature References

PubMed ID	Title	Journal	Year
11960013	IRAK-4: a novel member of the IRAK family with the properties of an Li, S, Strelow, A, Fontana, EJ, Wesche, H	Proc Natl Acad Sci U S A	2002
14625308	Sequential autophosphorylation steps in the interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling Kollewe, C, Mackensen, AC, Neumann, D, Knop, J, Cao, P, Li, S, Wesche, H, Martin, MU	J Biol Chem	2004