GUK1 phosphorylates 6TdGMP to 6TdGDP

Stable Identifier
R-HSA-9748963
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
6TdGMP--MPK-->6TdGDP
ReviewStatus
5/5
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6-thioguanine nucleotides (6-TGNs) consist of 6-thio(deoxy)guanosine 5'-monophosphate (T(d)GMP), -diphosphate (T(d)GDP), and -triphosphate (T(d)GTP), representing the pharmacologically-active metabolites involved in drug action of thiopurines.

Guanylate kinase (GUK1) is an essential nucleoside monophosphate kinase that catalyzes the phosphorylation of deoxyguanosine-monophosphate (dGMP) to yield dGDP, an important precursor for nucleotide synthesis (Agarwal et al. 1978). As well as this physiological role, GUK1 converts therapeutic prodrugs into their pharmacologically active metabolites. In this example, GUK1 phosphorylates 6-thiodeoxyguanosine monophosphate (6TdGMP) to 6-thiodeoxyguanosine diphosphate (6TdGDP) (Miller et al. 1977, review in Karran 2006).
Literature References
PubMed ID Title Journal Year
197968 Reassessment of the interactions of guanylate kinase and 6-thioguanosine 5'-phosphate

Spector, T, Miller, RL, Adamczyk, DL

Biochem Pharmacol 1977
211390 Guanylate kinases from human erythrocytes, hog brain, and rat liver

Parks, Jr, RE, Agarwal, KC, Miech, RP

Methods Enzymol 1978
Participants
Participates
Event Information
Catalyst Activity

guanylate kinase activity of GUK1 [cytosol]

Orthologous Events
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