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GUK1 [cytosol]
Stable Identifier
R-HSA-58048
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
guanylate kinase 1, Guanylate kinase (EC 2.7.4.8) (GMP kinase), GMP kinase
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Azathioprine ADME (Homo sapiens)
GUK1 phosphorylates 6TGMP to 6TGDP (Homo sapiens)
GUK1 [cytosol] (Homo sapiens)
GUK1 phosphorylates 6TdGMP to 6TdGDP (Homo sapiens)
GUK1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of nucleotides (Homo sapiens)
Interconversion of nucleotide di- and triphosphates (Homo sapiens)
(d)GDP + ADP <=> (d)GMP + ATP (GUK1) (Homo sapiens)
GUK1 [cytosol] (Homo sapiens)
(d)GMP + ATP <=> (d)GDP + ADP (GUK1) (Homo sapiens)
GUK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16774 GUK1
Gene Names
GUK1, GMK, GMPK
Chain
initiator methionine:, chain:2-197
Reference Genes
BioGPS Gene:2987 GUK1
COSMIC (genes):GUK1 GUK1
CTD Gene:2987 GUK1
dbSNP Gene:2987 GUK1
ENSEMBL:ENSG00000143774 GUK1
HGNC:4693 GUK1
KEGG:hsa:2987 GUK1
Monarch:2987 GUK1
NCBI Gene:2987 GUK1
OMIM:139270 GUK1
UCSC:Q16774 GUK1
Reference Transcript
RefSeq:NM_001159390.1 GUK1
RefSeq:NM_000858.5 GUK1
RefSeq:NM_001159391.1 GUK1
RefSeq:NM_001242840.1 GUK1
RefSeq:NM_001242839.1 GUK1
Other Identifiers
11729480_a_at
11729481_s_at
11756553_a_at
11757299_x_at
16657233
16657235
16657237
16657239
16657241
16657249
16657251
16657253
16657255
16657259
16657261
16657263
16678322
18670620
18670621
18670622
18670623
18670624
18670625
18670626
18670627
18670628
18670629
18670630
18670631
18670632
18670633
18670634
18670635
18670636
18670637
18670638
18670639
18670640
18670641
200075_PM_s_at
200075_s_at
2383860
2383861
2383862
2383864
2383865
2383866
2383867
2383868
2383869
2383870
2383871
2383872
2383873
2383874
2383875
2383876
2383877
2383878
2383879
2383880
2383881
2383882
2383883
2383884
2383885
2383886
2383887
2383888
2383889
2383890
2383891
2383892
2383893
2383894
2383895
2383896
2383898
2383900
2383902
2383916
2383917
2987
7892681
7892851
7892968
7893016
7893395
7893855
7894068
7894389
7894824
7894977
7895147
7896162
7896360
7896529
7896530
7910241
905_at
A_14_P107324
A_14_P114850
A_23_P201097
A_24_P336441
A_33_P3399291
GE57786
GO:0001917
GO:0003824
GO:0004385
GO:0005515
GO:0005524
GO:0005737
GO:0005739
GO:0005829
GO:0006163
GO:0006185
GO:0006805
GO:0015949
GO:0016301
GO:0016740
GO:0019673
GO:0034436
GO:0043226
GO:0046037
GO:0046054
GO:0046060
GO:0046710
GO:0046711
GO:0055086
GO:1901135
HMNXSV003022663
ILMN_1758398
L76200_at
PH_hs_0018347
TC01005084.hg
g13623296_3p_s_at
Inferred To
Homologues of GUK1 [cytosol]
(Sus scrofa)
guk1b [cytosol]
(Danio rerio)
Guk1 [cytosol]
(Rattus norvegicus)
oya [cytosol]
(Drosophila melanogaster)
guk1 [cytosol]
(Xenopus tropicalis)
GUK1 [cytosol]
(Bos taurus)
GUK1 [cytosol]
(Canis familiaris)
GUK1 [cytosol]
(Dictyostelium discoideum)
GUK1 [cytosol]
(Gallus gallus)
GUK1 [cytosol]
(Mus musculus)
GUK1 [cytosol]
(Plasmodium falciparum)
GUK1 [cytosol]
(Saccharomyces cerevisiae)
GUK1 [cytosol]
(Schizosaccharomyces pombe)
GUK1 [cytosol]
(Sus scrofa)
guk-1 [cytosol]
(Caenorhabditis elegans)
Cross References
ENSEMBL
ENST00000453943
,
ENSP00000355691
,
ENST00000366728
,
ENSP00000401832
,
ENSP00000355689
,
ENST00000366730
OpenTargets
ENSG00000143774
IntEnz
2.7.4.8
HPA
ENSG00000143774-GUK1
ZINC - Substances
KGUA_HUMAN
ZINC target
Q16774
PRO
Q16774
Pharos - Targets
Q16774
HMDB Protein
HMDBP00930
PDB
6NUI
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6DKK2 TTC19
1
TTC19 [mitochondrial inner membrane]
(R-HSA-9906047)
0.589
2
UniProt:Q5BJF2 SGMR2
0.527
2
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