GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene

Stable Identifier
R-HSA-9734353
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
3/5
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GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene
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After initial activation of NKX2-5 and GATA4 by MESP1, GATA4 binds the promoter of the NKX2-5 gene and activates transcription (inferred from mouse homologs). SMAD1:SMAD4 complexes that are apparently activated by BMP signaling also bind the NKX2-5 promoter, recruit GATA4, and synergistically enhance transcription (inferred from mouse homologs). TBX20 binds the cardiac enhancer of the NKX2-5 promoter and activates transcription (inferred from mouse homologs)
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Inferred From
Gata4, Smad1:Smad4, Mef2c, Tbx20, and Nkx2-5 bind the Nkx2-5 gene (Mus musculus)
Authored
May, B  (2021-06-10)
Created
May, B  (2021-06-17)
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