Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
GATA4 [nucleoplasm]
Stable Identifier
R-HSA-400553
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor GATA-4, GATA4_HUMAN, GATA-binding Factor 4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Cardiogenesis (Homo sapiens)
Expression of GATA4 in cardiogenesis (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of HAND1 in cardiogenesis (Homo sapiens)
GATA4:NKX2-5:HAND1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of HAND2 in cardiogenesis (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of ISL1 in cardiogenesis (Homo sapiens)
GATA4:LEF1:CTNNB1:ISL1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of MEF2C in cardiogenesis (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of NKX2-5 in cardiogenesis (Homo sapiens)
GATA4:SMAD1:SMAD4:MEF2C:NKX2-5:TBX20:NKX2-5 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4 and LEF1:CTNNB1 bind the ISL1 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:LEF1:CTNNB1:ISL1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:NKX2-5:HAND1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:SMAD1:SMAD4:MEF2C:NKX2-5:TBX20:NKX2-5 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
HEY1,HEY2 bind GATA4,GATA6 (Homo sapiens)
GATA4,6 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
HEY1,2:GATA4,6 [nucleoplasm] (Homo sapiens)
GATA4,6 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Developmental Cell Lineages (Homo sapiens)
Developmental Cell Lineages of the Exocrine Pancreas (Homo sapiens)
Developmental Lineage of Multipotent Pancreatic Progenitor Cells (Homo sapiens)
Definitive endoderm cell produces dorsal foregut endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Definitive endoderm cell produces ventral foregut endoderm cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Dorsal foregut endoderm cell produces duodeno-pancreatic endoderm cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Duodeno-pancreatic endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Ventral foregut endoderm cell produces primary multipotent pancreatic progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Developmental Lineage of Pancreatic Acinar Cells (Homo sapiens)
Pancreatic pro-acinar cell produces pancreatic acinar cell (Homo sapiens)
pancreatic acinar cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
pancreatic pro-acinar cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Pancreatic tip progenitor cell produces pancreatic pro-acinar cell (Homo sapiens)
pancreatic pro-acinar cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
pancretic tip progenitor cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces pancreatic tip progenitor cell (Homo sapiens)
pancretic tip progenitor cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Developmental Lineage of Pancreatic Ductal Cells (Homo sapiens)
Primary multipotent pancreatic progenitor cell produces trunk bipotent pancreatic progenitor cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Gastrulation (Homo sapiens)
Formation of definitive endoderm (Homo sapiens)
Expression of GATA4 in definitive endoderm (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of SOX17 in definitive endoderm (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Formation of lateral plate mesoderm (Homo sapiens)
Expression of BMP4 in lateral plate mesoderm (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:BMP4 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of GATA4 in lateral plate mesoderm (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4 binds the BMP4 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
GATA4:BMP4 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Transcriptional regulation of testis differentiation (Homo sapiens)
Expression of AMH in testis differentiation (Homo sapiens)
SOX9:NR5A1:GATA4:AMH gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of DMRT1 in testis differentiation (Homo sapiens)
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of SRY in testis differentiation (Homo sapiens)
WT1:NR5A1:GATA4:ZFPM2:SRY gene [nucleoplasm] (Homo sapiens)
GATA4:ZFPM2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9:NR5A1:GATA4:AMH gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
WT1:NR5A1:GATA4:ZFPM2:SRY gene [nucleoplasm] (Homo sapiens)
GATA4:ZFPM2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
ZFPM proteins bind GATA proteins (Homo sapiens)
GATA proteins [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
ZFPM proteins:GATA proteins [nucleoplasm] (Homo sapiens)
GATA proteins [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43694 GATA4
Gene Names
GATA4
Chain
chain:1-442
Reference Genes
BioGPS Gene:2626 GATA4
COSMIC (genes):GATA4 GATA4
CTD Gene:2626 GATA4
dbSNP Gene:2626 GATA4
ENSEMBL:ENSG00000136574 GATA4
HGNC:4173 GATA4
KEGG:hsa:2626 GATA4
Monarch:2626 GATA4
NCBI Gene:2626 GATA4
OMIM:600576 GATA4
UCSC:P43694 GATA4
Reference Transcript
RefSeq:NM_001308093.1 GATA4
RefSeq:XM_011543817.2 GATA4
RefSeq:XM_005272385.4 GATA4
RefSeq:XM_005272386.1 GATA4
RefSeq:NM_002052.4 GATA4
RefSeq:XM_006716248.1 GATA4
RefSeq:XM_017013312.1 GATA4
RefSeq:XM_011543818.2 GATA4
Other Identifiers
11725540_a_at
11725541_a_at
11725542_a_at
1553131_PM_a_at
1553131_a_at
1570276_PM_a_at
1570276_a_at
17065780
205517_PM_at
205517_at
2626
3086101
3086103
3086109
3086110
3086111
3086113
3086114
3086115
3086116
3086117
3086118
3086119
3086120
3086121
3086122
3086123
3086124
3086125
3086126
3086146
3086150
3086151
3086156
3086157
3086158
3086159
3086160
3086161
3086162
3086163
3114589
34241_at
8144643
A_23_P384761
A_33_P3293456
A_33_P3360363
A_33_P3406962
GE81107
GE88108
GO:0000122
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001216
GO:0001228
GO:0001947
GO:0003162
GO:0003180
GO:0003190
GO:0003197
GO:0003208
GO:0003215
GO:0003281
GO:0003289
GO:0003290
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0007267
GO:0007492
GO:0007507
GO:0008270
GO:0008584
GO:0009410
GO:0009612
GO:0009653
GO:0009888
GO:0010507
GO:0010575
GO:0010667
GO:0016604
GO:0019901
GO:0022414
GO:0023052
GO:0030154
GO:0030513
GO:0033189
GO:0035054
GO:0036302
GO:0042060
GO:0043226
GO:0043565
GO:0045165
GO:0045766
GO:0045893
GO:0045944
GO:0046872
GO:0048617
GO:0048731
GO:0048856
GO:0051525
GO:0055007
GO:0060290
GO:0060413
GO:0060575
GO:0061026
GO:0061049
GO:0061629
GO:0070410
GO:0071333
GO:0086004
GO:0090575
GO:0140110
GO:0140297
GO:1902176
GO:1990837
GO:2001234
HMNXSV003008431
HMNXSV003056245
Hs.243987.0.S3_3p_at
Hs2.243987.1.S1_3p_s_at
Hs2.243987.4.A1_3p_s_at
ILMN_1749866
L34357_at
PH_hs_0013002
TC08000089.hg
Participates
as a component of
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
GATA4:BMP4 gene [nucleoplasm] (Homo sapiens)
TCF7L2:CTNNB1:EOMES:TBXT:MIXL1:p-2S-SMAD2,3:SMAD4:FOXA2:GATA4:GATA6,SOX17 gene [nucleoplasm] (Homo sapiens)
GATA4:ZFPM2 [nucleoplasm] (Homo sapiens)
SOX9:NR5A1:GATA4:AMH gene [nucleoplasm] (Homo sapiens)
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
GATA4:SMAD1:SMAD4:MEF2C:NKX2-5:TBX20:NKX2-5 gene [nucleoplasm] (Homo sapiens)
GATA4:ISL1:LDB1:NKX2-5:TBX20:MEF2C gene [nucleoplasm] (Homo sapiens)
GATA4:LEF1:CTNNB1:ISL1 gene [nucleoplasm] (Homo sapiens)
GATA4:GATA6:ISL1:LDB1:HAND2 gene [nucleoplasm] (Homo sapiens)
GATA4:NKX2-5:HAND1 gene [nucleoplasm] (Homo sapiens)
as an input of
TCF7L2:CTNNB1, EOMES, TBXT, MIXL1, SMAD2,3, FOXA2, GATA4, and GATA6 bind the SOX17 gene (Homo sapiens)
GATA4 binds the BMP4 gene (Homo sapiens)
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)
SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)
GATA4, SMAD1:SMAD4, MEF2C, TBX20, and NKX2-5 bind the NKX2-5 gene (Homo sapiens)
GATA4, ISL1:LDB1, TBX20, and NKX2-5 bind the MEF2C gene (Homo sapiens)
GATA4, GATA6, and ISL1:LDB1 bind the HAND2 gene (Homo sapiens)
GATA4 and LEF1:CTNNB1 bind the ISL1 gene (Homo sapiens)
GATA4 and NKX2-5 bind the HAND1 gene (Homo sapiens)
as an output of
Expression of GATA4 in definitive endoderm (Homo sapiens)
Expression of GATA4 in lateral plate mesoderm (Homo sapiens)
Expression of GATA4 in cardiogenesis (Homo sapiens)
as a member of
GATA proteins [nucleoplasm] (Homo sapiens)
GATA4,6 [nucleoplasm] (Homo sapiens)
as a protein marker of
pancreatic acinar cell (Homo sapiens)
primary multipotent pancreatic progenitor cell (Homo sapiens)
definitive endoderm cell (Homo sapiens)
duodeno-pancreatic endoderm cell (Homo sapiens)
pancretic tip progenitor cell (Homo sapiens)
pancreatic pro-acinar cell (Homo sapiens)
This entity regulates
Positively
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells
(Homo sapiens)
Inferred To
GATA4 [nucleoplasm]
(Bos taurus)
GATA4 [nucleoplasm]
(Canis familiaris)
GATA4 [nucleoplasm]
(Gallus gallus)
GATA4 [nucleoplasm]
(Sus scrofa)
gata4 [nucleoplasm]
(Danio rerio)
gata4 [nucleoplasm]
(Xenopus tropicalis)
Gata4 [nucleoplasm]
(Mus musculus)
Gata4 [nucleoplasm]
(Rattus norvegicus)
pnr [nucleoplasm]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENSG00000285109
,
ENSP00000334458
,
ENSG00000136574
,
ENSP00000493647
,
ENST00000647274
,
ENST00000532059
,
ENSP00000435712
,
ENSP00000482268
,
ENSP00000495511
,
ENST00000622443
,
ENST00000335135
,
ENST00000643249
OpenTargets
ENSG00000136574
GeneCards
GATA4
HPA
ENSG00000136574-GATA4
PRO
P43694
Pharos - Targets
P43694
GlyGen
P43694
Orphanet
GATA4
PDB
2M9W
,
8VG1
,
8VG0
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2Y9 KLF13
0.524
3
UniProt:P52952 NKX2-5
1
NKX2-5 [nucleoplasm]
(R-HSA-4005994)
0.524
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text