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GATA4 [nucleoplasm]
Stable Identifier
R-HSA-400553
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor GATA-4, GATA4_HUMAN, GATA-binding Factor 4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Transcriptional regulation of testis differentiation (Homo sapiens)
Expression of AMH in testis differentiation (Homo sapiens)
SOX9:NR5A1:GATA4:AMH gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of DMRT1 in testis differentiation (Homo sapiens)
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Expression of SRY in testis differentiation (Homo sapiens)
WT1:NR5A1:GATA4:ZFPM2:SRY gene [nucleoplasm] (Homo sapiens)
GATA4:ZFPM2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
SOX9:NR5A1:GATA4:AMH gene [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
WT1:NR5A1:GATA4:ZFPM2:SRY gene [nucleoplasm] (Homo sapiens)
GATA4:ZFPM2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
ZFPM proteins bind GATA proteins (Homo sapiens)
GATA proteins [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
ZFPM proteins:GATA proteins [nucleoplasm] (Homo sapiens)
GATA proteins [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Incretin synthesis, secretion, and inactivation (Homo sapiens)
Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) (Homo sapiens)
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Physiological factors (Homo sapiens)
Expression of NPPA (ANF) (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
GATA4 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43694 GATA4
Gene Names
GATA4
Chain
chain:1-442
Reference Genes
BioGPS Gene:2626 GATA4
COSMIC (genes):GATA4 GATA4
CTD Gene:2626 GATA4
dbSNP Gene:2626 GATA4
ENSEMBL:ENSG00000136574 GATA4
ENSEMBL:ENSG00000285109 GATA4
HGNC:4173 GATA4
KEGG Gene (Homo sapiens):2626 GATA4
Monarch:2626 GATA4
NCBI Gene:2626 GATA4
OMIM:600576 GATA4
UCSC:P43694 GATA4
Reference Transcript
RefSeq:XM_005272385.4 GATA4
RefSeq:XM_011543818.2 GATA4
RefSeq:NM_001308093.1 GATA4
RefSeq:XM_005272386.1 GATA4
RefSeq:XM_017013312.1 GATA4
RefSeq:XM_006716248.1 GATA4
RefSeq:NM_002052.4 GATA4
RefSeq:XM_011543817.2 GATA4
Other Identifiers
0000360025
11725540_a_at
11725541_a_at
11725542_a_at
1553131_a_at
1570276_a_at
17065780
205517_at
2626
3086111
3086114
3086115
3086116
3086117
3086118
3086119
3086120
3086121
3086122
3086146
3086150
3086151
3086157
3086158
3086159
3086160
3086161
3086162
3086163
3114589
34241_at
8144643
A_23_P384761
A_33_P3293456
A_33_P3360363
GE81107
GE88108
GO:0000003
GO:0000785
GO:0000976
GO:0000977
GO:0000978
GO:0000981
GO:0000987
GO:0001085
GO:0001216
GO:0001228
GO:0001947
GO:0003013
GO:0003162
GO:0003180
GO:0003190
GO:0003197
GO:0003208
GO:0003215
GO:0003281
GO:0003289
GO:0003290
GO:0003674
GO:0003677
GO:0003700
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0006355
GO:0006357
GO:0006464
GO:0006914
GO:0006950
GO:0007165
GO:0007267
GO:0007492
GO:0007596
GO:0008134
GO:0008150
GO:0008219
GO:0008270
GO:0008584
GO:0009056
GO:0009058
GO:0009612
GO:0009790
GO:0010507
GO:0010575
GO:0010667
GO:0016604
GO:0019899
GO:0019901
GO:0030154
GO:0030513
GO:0032991
GO:0033189
GO:0033613
GO:0034641
GO:0035054
GO:0036302
GO:0040007
GO:0042060
GO:0042493
GO:0042592
GO:0043167
GO:0043226
GO:0043565
GO:0045165
GO:0045766
GO:0045893
GO:0045944
GO:0046872
GO:0048617
GO:0048646
GO:0048856
GO:0051525
GO:0051891
GO:0051896
GO:0055007
GO:0060290
GO:0060413
GO:0060575
GO:0061026
GO:0061049
GO:0070374
GO:0070410
GO:0071333
GO:0086004
GO:0090575
GO:1903202
GO:1990837
GO:2001234
HMNXSV003008431
Hs.243987.0.S3_3p_at
Hs2.243987.1.S1_3p_s_at
Hs2.243987.4.A1_3p_s_at
ILMN_1749866
L34357_at
PH_hs_0013002
TC08000089.hg
Participates
as a member of
GATA proteins [nucleoplasm] (Homo sapiens)
as a component of
SOX9:GATA4:DMRT1 gene [nucleoplasm] (Homo sapiens)
SOX9:NR5A1:GATA4:AMH gene [nucleoplasm] (Homo sapiens)
GATA4:ZFPM2 [nucleoplasm] (Homo sapiens)
NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
as an input of
SOX9 and GATA4 bind the DMRT1 gene (Homo sapiens)
SOX9, NR5A1 (SF1), and GATA4 bind the AMH gene (Homo sapiens)
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
This entity regulates
Positively
Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells
(Homo sapiens)
Inferred To
GATA4 [nucleoplasm]
(Bos taurus)
GATA4 [nucleoplasm]
(Canis familiaris)
GATA4 [nucleoplasm]
(Sus scrofa)
GATA4 [nucleoplasm]
(Xenopus tropicalis)
gata4 [nucleoplasm]
(Danio rerio)
Gata4 [nucleoplasm]
(Mus musculus)
Gata4 [nucleoplasm]
(Rattus norvegicus)
pnr [nucleoplasm]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001295022.1
,
XP_011542120.1
,
XP_005272442.1
,
XP_006716311.1
,
NP_002043.2
,
XP_011542119.1
,
XP_005272443.1
,
XP_016868801.1
OpenTargets
ENSG00000136574
GeneCards
P43694
HPA
ENSG00000136574-GATA4
Ensembl
ENSP00000334458
,
ENSP00000495511
,
ENST00000335135
,
ENST00000532059
,
ENST00000643249
,
ENSG00000285109
,
ENST00000647274
,
ENSG00000136574
,
ENSP00000435712
,
ENSP00000493647
PRO
P43694
Pharos - Targets
P43694
Orphanet
16104
PDB
2M9W
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52952 NKX2-5
1
NKX2-5 [nucleoplasm]
(R-HSA-4005994)
0.524
2
UniProt:Q9Y2Y9 KLF13
0.524
3
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