Reactome | GATA4 [nucleoplasm]

GATA4 [nucleoplasm]

Stable Identifier

R-HSA-400553

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Transcription factor GATA-4, GATA4_HUMAN, GATA-binding Factor 4

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - YAP1- and WWTR1 (TAZ)-stimulated gene expression (Homo sapiens)
      - Expression of NPPA (ANF) (Homo sapiens)
        
        NKX2-5:GATA4:HIPK1,2 [nucleoplasm] (Homo sapiens)
        
        GATA4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P43694 GATA4

Gene Names

GATA4

Chain

chain:1-442

Reference Genes

BioGPS Gene:2626 GATA4

COSMIC (genes):GATA4 GATA4

CTD Gene:2626 GATA4

dbSNP Gene:2626 GATA4

ENSEMBL:ENSG00000136574 GATA4

ENSEMBL:ENSG00000285109 GATA4

HGNC:4173 GATA4

KEGG Gene (Homo sapiens):2626 GATA4

Monarch:2626 GATA4

NCBI Gene:2626 GATA4

OMIM:600576 GATA4

UCSC:P43694 GATA4

Reference Transcript

Other Identifiers

0000360025

11725540_a_at

11725541_a_at

11725542_a_at

1553131_a_at

1570276_a_at

17065780

205517_at

2626

3086111

3086114

3086115

3086116

3086117

3086118

3086119

3086120

3086121

3086122

3086146

3086150

3086151

3086157

3086158

3086159

3086160

3086161

3086162

3086163

3114589

34241_at

8144643

A_23_P384761

A_33_P3293456

A_33_P3360363

GE81107

GE88108

GO:0000003

GO:0000785

GO:0000976

GO:0000977

GO:0000978

GO:0000981

GO:0000987

GO:0001085

GO:0001216

GO:0001228

GO:0001947

GO:0003013

GO:0003162

GO:0003180

GO:0003190

GO:0003197

GO:0003208

GO:0003215

GO:0003281

GO:0003289

GO:0003290

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0006355

GO:0006357

GO:0006464

GO:0006914

GO:0006950

GO:0007165

GO:0007267

GO:0007492

GO:0007596

GO:0008134

GO:0008150

GO:0008219

GO:0008270

GO:0008584

GO:0009056

GO:0009058

GO:0009612

GO:0009790

GO:0010507

GO:0010575

GO:0010667

GO:0016604

GO:0019899

GO:0019901

GO:0030154

GO:0030513

GO:0032991

GO:0033189

GO:0033613

GO:0034641

GO:0035054

GO:0036302

GO:0040007

GO:0042060

GO:0042493

GO:0042592

GO:0043167

GO:0043226

GO:0043565

GO:0045165

GO:0045766

GO:0045893

GO:0045944

GO:0046872

GO:0048617

GO:0048646

GO:0048856

GO:0051525

GO:0051891

GO:0051896

GO:0055007

GO:0060290

GO:0060413

GO:0060575

GO:0061026

GO:0061049

GO:0070374

GO:0070410

GO:0071333

GO:0086004

GO:0090575

GO:1903202

GO:1990837

GO:2001234

HMNXSV003008431

Hs.243987.0.S3_3p_at

Hs2.243987.1.S1_3p_s_at

Hs2.243987.4.A1_3p_s_at

ILMN_1749866

L34357_at

PH_hs_0013002

TC08000089.hg

Participates

as a member of

GATA proteins [nucleoplasm] (Homo sapiens)

as a component of

as an input of

This entity regulates

Positively

Synthesis of prepro-Glucose-dependent Insulinotropic Polypeptide (preproGIP) in intestinal K cells (Homo sapiens)

Inferred To

GATA4 [nucleoplasm] (Bos taurus)

GATA4 [nucleoplasm] (Canis familiaris)

GATA4 [nucleoplasm] (Sus scrofa)

GATA4 [nucleoplasm] (Xenopus tropicalis)

gata4 [nucleoplasm] (Danio rerio)

Gata4 [nucleoplasm] (Mus musculus)

Gata4 [nucleoplasm] (Rattus norvegicus)

pnr [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001295022.1, XP_011542120.1, XP_005272442.1, XP_006716311.1, NP_002043.2, XP_011542119.1, XP_005272443.1, XP_016868801.1

OpenTargets

ENSG00000136574

GeneCards

P43694

HPA

ENSG00000136574-GATA4

Ensembl

ENSP00000334458, ENSP00000495511, ENST00000335135, ENST00000532059, ENST00000643249, ENSG00000285109, ENST00000647274, ENSG00000136574, ENSP00000435712, ENSP00000493647

PRO

P43694

Pharos - Targets

P43694

Orphanet

16104

PDB

2M9W

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52952 NKX2-5	1	NKX2-5 [nucleoplasm] (R-HSA-4005994)	0.524	2
UniProt:Q9Y2Y9 KLF13			0.524	3