SARS-CoV-2 nsp8 binds to 7SL RNA

Stable Identifier
R-HSA-9729841
Type
Reaction [binding]
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
Compartment
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Signal recognition particle (SRP) triggers ribosome translocation to the endoplasmic reticulum to ensure proper folding and trafficking of hydrophobic proteins to the cell membrane (Akopian et al, 2013).

SARS-CoV-2 infection suppresses protein integration into the cell membrane. SARS-CoV-2 nonstructural protein 8 (nsp8) binds at a distinct and highly specific region in the S domain of the 7SL RNA scaffold of SRP, namely in the region bound by SRP54 (the protein responsible for signal peptide recognition, SRP-receptor binding, and ribosome translocation, leading to suppression of protein integration into the cell membrane. This suggests that SARS-CoV-2-mediated suppression of SRP-dependent protein secretion enables suppression of host immune defenses (Banerjee et al, 2020).

Literature References
PubMed ID Title Journal Year
23414305 Signal recognition particle: an essential protein-targeting machine

Akopian, D, Shan, SO, Zhang, X, Shen, K

Annu Rev Biochem 2013
33080218 SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Thai, J, Bruce, EA, Honson, DD, Ollikainen, N, Botten, JW, Miller, ZD, Voorhees, RM, Goldfarb, D, Guttman, M, Schmidt, MM, Chow, A, Blanco, MR, Quinodoz, SA, Majumdar, D, Bhat, P, Lin, AE, Stewart, DG, Banerjee, AK, Loney, C, Rihn, SJ, De Lorenzo, G, Chen, LM

Cell 2020
Participants
Participates
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Reviewed
Created
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