SARS-CoV-2 modulates host translation machinery

Stable Identifier
R-HSA-9754678
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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SARS-CoV-2 modulates host translation machinery
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SARS-CoV-2 encodes several proteins that have been implicated in shutting off host expression (Banerjee AK et al. 2020; Finkel Y et al. 2021). This Reactome module describes SARS-CoV-2 nonstructural protein 1 (nsp1)-mediated shutdown of host protein translation by binding to the mRNA entrance channel on the 40S subunit (Banerjee AK et al. 2020), SARS-CoV-2 nsp16-mediated disruption of global mRNA splicing via binding to the 5′ splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome (Banerjee et al, 2020), and SARS-CoV-2 nsp8, nsp9-mediated suppression of protein integration into the cell membrane (Banerjee et al, 2020).
Literature References
PubMed ID Title Journal Year
32680882 Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Cheng, J, Ameismeier, M, Beckmann, R, Hayn, M, Thoms, M, Berninghausen, O, Kirchhoff, F, Buschauer, R, Hirschenberger, M, Becker, T, Denk, T, Sparrer, KMJ, Fröhlich, T, Straub, JH, Mackens-Kiani, T, Koepke, L, Stürzel, CM, Kratzat, H

Science 2020
33080218 SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

Thai, J, Bruce, EA, Honson, DD, Ollikainen, N, Botten, JW, Miller, ZD, Voorhees, RM, Goldfarb, D, Guttman, M, Schmidt, MM, Chow, A, Blanco, MR, Quinodoz, SA, Majumdar, D, Bhat, P, Lin, AE, Stewart, DG, Banerjee, AK, Loney, C, Rihn, SJ, De Lorenzo, G, Chen, LM

Cell 2020
Participants
Events
Participates
as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Authored
Stephan, R  (2021-05-03)
Shamovsky, V  (2021-10-27)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2021-09-30)
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