OTOP1 transports H+ from the extracellular region to the cytosol

Stable Identifier
R-HSA-9729542
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In the presence of extracellular acids, the OTOP1 channel passively transports H+ ions along the concentration gradient from the extracellular region to the cytosol (inferred from the mouse homolog). OTOP1 is expressed in type III taste cells where it is responsible for activating depolarization in response to sour (acidic) compounds.

Literature References
PubMed ID Title Journal Year
29371428 An evolutionarily conserved gene family encodes proton-selective ion channels

Tu, YH, Cooper, AJ, Teng, B, Chang, RB, Artiga, DJ, Turner, HN, Mulhall, EM, Ye, W, Smith, AD, Liman, ER

Science 2018
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Output
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Catalyst Activity

proton channel activity of OTOP1 [plasma membrane]

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