SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

Stable Identifier
R-HSA-9717382
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
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SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol
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SCN9A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Klugbauer et al. 1995, Cummins et al. 2004, Cox et al. 2006, Estacion et al. 2009, Korner et al. 2018, Sokolov et al. 2018). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009).
Literature References
PubMed ID Title Journal Year
20033988 A sodium channel gene SCN9A polymorphism that increases nociceptor excitability

Harty, TP, Choi, JS, Estacion, M, Dib-Hajj, SD, Waxman, SG, Tyrrell, L

Ann Neurol 2009
15385606 Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy

Cummins, TR, Dib-Hajj, SD, Waxman, SG

J Neurosci 2004
29659026 β1 subunit stabilises sodium channel Nav1.7 against mechanical stress

Machtens, JP, Lampert, A, Meents, J, Körner, J

J Physiol 2018
17167479 An SCN9A channelopathy causes congenital inability to experience pain

Nicholas, AK, Valente, EM, Cox, JJ, Mannan, J, Jafri, H, Gribble, FM, Springell, K, Thornton, G, Woods, CG, Gorman, S, McHale, DP, Hamamy, H, Al-Gazali, L, Wood, JN, Roberts, E, Raashid, Y, Williams, R, Karbani, G, Reimann, F

Nature 2006
7720699 Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells

Klugbauer, N, Lacinova, L, Flockerzi, V, Hofmann, F

EMBO J 1995
29744740 Co-expression of β Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and Phosphorylation and Their Effects on Channel Pharmacology and Biophysics

Sokolov, MV, Raynoschek, C, Dabrowski, M, Main, M, Franzén, B, Larsson, O, Henrich-Noack, P

J Mol Neurosci 2018
Participants
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Output
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as an event of
Catalyst Activity

sodium channel activity of SCN9A:SCN1B,2B,4B [plasma membrane]

Physical Entity
SCN9A:SCN1B,2B,4B [plasma membrane] (Homo sapiens)
Activity
sodium channel activity (GO:0005272)
Inferred From
Scn9a:Scn1b,2b,4b transports Na+ from the extracellular region to the cytosol (Mus musculus)
Cross References
Rhea
Authored
May, B  (2021-03-10)
Reviewed
Jiang, P  (2021-08-08)
Created
May, B  (2021-03-10)
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