Reactome | SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

Stable Identifier

R-HSA-9717382

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SCN9A:SCN1B,2B,4B transports Na+ from the extracellular region to the cytosol

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SCN9A in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Klugbauer et al. 1995, Cummins et al. 2004, Cox et al. 2006, Estacion et al. 2009, Korner et al. 2018, Sokolov et al. 2018). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
20033988	A sodium channel gene SCN9A polymorphism that increases nociceptor excitability Estacion, M, Harty, TP, Choi, JS, Tyrrell, L, Dib-Hajj, SD, Waxman, SG	Ann Neurol	2009
15385606	Electrophysiological properties of mutant Nav1.7 sodium channels in a painful inherited neuropathy Cummins, TR, Dib-Hajj, SD, Waxman, SG	J Neurosci	2004
29659026	β1 subunit stabilises sodium channel Nav1.7 against mechanical stress Körner, J, Meents, J, Machtens, JP, Lampert, A	J Physiol	2018
17167479	An SCN9A channelopathy causes congenital inability to experience pain Cox, JJ, Reimann, F, Nicholas, AK, Thornton, G, Roberts, E, Springell, K, Karbani, G, Jafri, H, Mannan, J, Raashid, Y, Al-Gazali, L, Hamamy, H, Valente, EM, Gorman, S, Williams, R, McHale, DP, Wood, JN, Gribble, FM, Woods, CG	Nature	2006
7720699	Structure and functional expression of a new member of the tetrodotoxin-sensitive voltage-activated sodium channel family from human neuroendocrine cells Klugbauer, N, Lacinova, L, Flockerzi, V, Hofmann, F	EMBO J	1995
29744740	Co-expression of β Subunits with the Voltage-Gated Sodium Channel Na_V1.7: the Importance of Subunit Association and Phosphorylation and Their Effects on Channel Pharmacology and Biophysics Sokolov, MV, Henrich-Noack, P, Raynoschek, C, Franzén, B, Larsson, O, Main, M, Dabrowski, M	J Mol Neurosci	2018