Reactome | Scn9a:Scn1b,2b,4b transports Na+ from the extracellular region to the cytosol

Scn9a:Scn1b,2b,4b transports Na+ from the extracellular region to the cytosol

Stable Identifier

R-MMU-9717440

Type

Reaction [transition]

Species

Mus musculus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Scn9a:Scn1b,2b,4b transports Na+ from the extracellular region to the cytosol

Scn9a in combination with a regulatory beta subunit responds to depolarization by opening and passively transporting sodium ions according to the concentration gradient from the extracellular region to the cytosol (Gao et al. 2009). In mouse type II taste cells, initial depolarization at the apex of the cell is believed to cause an activation potential via Scn2a, Scn3a, and Scn9a located at the basolateral membrane (Gao et al. 2009). Beta units Scn1b, Scn2b, and Scn4b are expressed in taste cells (Shandilya et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
27787515	AP1 transcription factors are required to maintain the peripheral taste system Medler, KF, Roberts, SG, Nayak, TK, Gao, Y, Shandilya, J	Cell Death Dis	2016
19284629	Voltage-gated sodium channels in taste bud cells Williams, ME, Moyer, BD, Hevezi, P, Lu, M, Kalabat, D, Zlotnik, A, Echeverri, F, Laita, B, Gao, N	BMC Neurosci	2009