Miro GTPases are a separate family of Ras-related GTPases that are sometimes included in the atypical RHO GTPases group, but are phylogenetically distinct from the Rho family (Jaffe and Hall 2005; Boureux et al. 2007; Devine et al. 2016; Liu et al. 2017). Miro GTPases possess an additional GTPase domain more closely related to Rheb (Klosowiak et al. 2013). Miro family of RAS-like GTPases includes two members, RHOT1 and RHOT2. RHOT1 and RHOT2 regulate the movement of mitochondria (Schwarz 2013; Devine et al. 2016) and peroxisomes (Castro et al. 2018, Okumoto et al. 2018, Covill-Cooke et al. 2020).
Landahl, EC, Focia, PJ, Klosowiak, JL, Freymann, DM, Rice, SE, Chakravarthy, S
Liu, WN, Yan, M, Chan, AM
Schwarz, TL
Hall, A, Jaffe, AB
Schrader, TA, Schrader, M, Metz, J, Passmore, JB, Ribeiro, D, Costello, JL, Castro, IG, Richards, DM, Gouveia, A
Covill-Cooke, C, Lopez-Domenech, G, Birsa, N, Kittler, JT, Toncheva, VS, Drew, J
Fort, P, Faure, S, Vignal, E, Boureux, A
Devine, MJ, Birsa, N, Kittler, JT
Okumoto, K, Nagata, A, Toyama, R, Ono, T, Shimomura, A, Fujiki, Y
© 2022 Reactome
