Miro GTPase Cycle

Stable Identifier
R-HSA-9715370
Type
Pathway
Species
Homo sapiens
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Miro GTPases are a separate family of Ras-related GTPases that are sometimes included in the atypical RHO GTPases group, but are phylogenetically distinct from the Rho family (Jaffe and Hall 2005; Boureux et al. 2007; Devine et al. 2016; Liu et al. 2017). Miro GTPases possess an additional GTPase domain more closely related to Rheb (Klosowiak et al. 2013). Miro family of RAS-like GTPases includes two members, RHOT1 and RHOT2. RHOT1 and RHOT2 regulate the movement of mitochondria (Schwarz 2013; Devine et al. 2016) and peroxisomes (Castro et al. 2018, Okumoto et al. 2018, Covill-Cooke et al. 2020).

Literature References
PubMed ID Title Journal Year
28610953 A thirty-year quest for a role of R-Ras in cancer: from an oncogene to a multitasking GTPase

Liu, WN, Yan, M, Chan, AM

Cancer Lett. 2017
24071720 Structural coupling of the EF hand and C-terminal GTPase domains in the mitochondrial protein Miro

Klosowiak, JL, Focia, PJ, Chakravarthy, S, Landahl, EC, Freymann, DM, Rice, SE

EMBO Rep 2013
23732472 Mitochondrial trafficking in neurons

Schwarz, TL

Cold Spring Harb Perspect Biol 2013
16212495 Rho GTPases: biochemistry and biology

Jaffe, AB, Hall, A

Annu Rev Cell Dev Biol 2005
29364559 A role for Mitochondrial Rho GTPase 1 (MIRO1) in motility and membrane dynamics of peroxisomes

Castro, IG, Richards, DM, Metz, J, Costello, JL, Passmore, JB, Schrader, TA, Gouveia, A, Ribeiro, D, Schrader, M

Traffic 2018
31894645 Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2

Covill-Cooke, C, Toncheva, VS, Drew, J, Birsa, N, Lopez-Domenech, G, Kittler, JT

EMBO Rep 2020
17035353 Evolution of the Rho family of ras-like GTPases in eukaryotes

Boureux, A, Vignal, E, Faure, S, Fort, P

Mol Biol Evol 2007
26707701 Miro sculpts mitochondrial dynamics in neuronal health and disease

Devine, MJ, Birsa, N, Kittler, JT

Neurobiol. Dis. 2016
29222186 New splicing variants of mitochondrial Rho GTPase-1 (Miro1) transport peroxisomes

Okumoto, K, Ono, T, Toyama, R, Shimomura, A, Nagata, A, Fujiki, Y

J Cell Biol 2018
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