RHOT2 GTPase cycle

Stable Identifier
R-HSA-9013419
Type
Pathway
Species
Homo sapiens
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This pathway catalogues guanine nucleotide exchange factors (GEFs) and effectors of RHOT2 (also known as MIRO-2). RHOT2 possesses a high intrinsic GTP-ase activity and does not require a GTPase activator protein (GAP) (Peters et al. 2018). No GDP dissociation inhibitors (GDIs) have been reported to interact with RHOT2. RHOT2 is a mitochondrial RHO GTPase. Like related RHOT1 (MIRO-1), RHOT2 localizes to the outer mitochondrial membrane. Similar to RHOT1, RHOT2 regulates mitochondrial movement by coupling mitochondria to kinesin and dynein motors that transport them along microtubules (Devine et al. 2016). RHOT2 is also localized to peroxisomes and it is involved in peroxisomal dynamics (Covill-Cooke et al. 2020).

Literature References
PubMed ID Title Journal Year
30513825 Human Miro Proteins Act as NTP Hydrolases through a Novel, Non-Canonical Catalytic Mechanism

Peters, DT, Kay, L, Eswaran, J, Lakey, JH, Soundararajan, M

Int J Mol Sci 2018
31894645 Peroxisomal fission is modulated by the mitochondrial Rho-GTPases, Miro1 and Miro2

Covill-Cooke, C, Toncheva, VS, Drew, J, Birsa, N, Lopez-Domenech, G, Kittler, JT

EMBO Rep 2020
26707701 Miro sculpts mitochondrial dynamics in neuronal health and disease

Devine, MJ, Birsa, N, Kittler, JT

Neurobiol. Dis. 2016
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