RAC2 translocates to the mitochondrial membrane

Stable Identifier
R-HSA-9714480
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, mitochondrial outer membrane
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RAC2 translocates to the mitochondrial membrane
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Based on its association with several mitochondrial outer membrane proteins and on mitochondrial defects observed in RAC2 deficient cells, RAC2 can likely localize to the mitochondrial outer membrane (Capala et al. 2015).

Literature References
PubMed ID Title Journal Year
26016997 Mitochondrial Dysfunction in Human Leukemic Stem/Progenitor Cells upon Loss of RAC2

Capala, ME, Maat, H, Bonardi, F, van den Boom, V, Kuipers, J, Vellenga, E, Giepmans, BN, Schuringa, JJ

PLoS One 2015
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Orthologous Events
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RAC2 translocates to the mitochondrial membrane (Caenorhabditis elegans)
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RAC2 translocates to the mitochondrial membrane (Danio rerio)
RAC2 translocates to the mitochondrial membrane (Dictyostelium discoideum)
RAC2 translocates to the mitochondrial membrane (Drosophila melanogaster)
RAC2 translocates to the mitochondrial membrane (Gallus gallus)
RAC2 translocates to the mitochondrial membrane (Mus musculus)
RAC2 translocates to the mitochondrial membrane (Rattus norvegicus)
RAC2 translocates to the mitochondrial membrane (Sus scrofa)
RAC2 translocates to the mitochondrial membrane (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2020-07-14)
Rothfels, K  (2020-07-14)
Reviewed
Fort, P  (2021-02-05)
Created
Orlic-Milacic, M  (2021-02-11)
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