ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region

Stable Identifier
R-HSA-9712204
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ANO2:Ca2+ translocates Cl- from the cytosol to the extracellular region
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Each monomer of the ANO2 dimer contains a pore that translocates chloride ions according to the concentration gradient from the cytosol to the extracellular region (Stöhr et al. 2009, and inferred from mouse homologs). Binding of calcium ions to sites in a transmembrane helix of each monomer increases the permeability of the pore to chloride ions.
Literature References
PubMed ID Title Journal Year
19474308 TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals

Stöhr, H, Heisig, JB, Benz, PM, Schöberl, S, Milenkovic, VM, Strauss, O, Aartsen, WM, Wijnholds, J, Weber, BH, Schulz, HL

J Neurosci 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

chloride channel activity of ANO2:Ca2+ [plasma membrane]

Physical Entity
ANO2:Ca2+ [plasma membrane] (Homo sapiens)
Activity
chloride channel activity (GO:0005254)
Inferred From
Ano2 dimer:Ca2+ translocates Cl- from the cytosol to the extracellular region (Mus musculus)
Cross References
RHEA
Authored
May, B  (2021-01-16)
Reviewed
Raimondi, F  (2021-08-02)
Created
May, B  (2021-01-16)
Cite Us!